Wall Shear Stress (WSS) Analysis in Atherosclerosis in Partial Ligated Apolipoprotein E Knockout Mouse Model through Computational Fluid Dynamics (CFD)
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作者:
Cho, Minju
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Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
Cho, Minju
[1
]
Hwang, Joon Seup
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Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
Hwang, Joon Seup
[1
]
Kim, Kyeong Ryeol
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Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
Kim, Kyeong Ryeol
[1
]
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Kim, Jun Ki
[1
,2
]
机构:
[1] Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
[2] Asan Med Ctr, Asan Inst Life Sci, Biomed Engn Res Ctr, Seoul 05505, South Korea
Atherosclerosis involves an inflammatory response due to plaque formation within the arteries, which can lead to ischemic stroke and heart disease. It is one of the leading causes of death worldwide, with various contributing factors such as hyperlipidemia, hypertension, obesity, diabetes, and smoking. Wall shear stress (WSS) is also known as a contributing factor of the formation of atherosclerotic plaques. Since the causes of atherosclerosis cannot be attributed to a single factor, clearly understanding the mechanisms and causes of its occurrence is crucial for preventing the disease and developing effective treatment strategies. To better understand atherosclerosis and define the correlation between various contributing factors, computational fluid dynamics (CFD) analysis is primarily used. CFD simulates WSS, the frictional force caused by blood flow on the vessel wall with various hemodynamic changes. Using apolipoprotein E knockout (ApoE-KO) mice subjected to partial ligation and a high-fat diet at 1-week, 2-week, and 4-week intervals as an atherosclerosis model, CFD analysis was conducted along with the reconstruction of carotid artery blood flow via magnetic resonance imaging (MRI) and compared to the inflammatory factors and pathological staining. In this experiment, a comparative analysis of the effects of high WSS and low WSS was conducted by comparing the standard deviation of time-averaged wall shear stress (TAWSS) at each point within the vessel wall. As a novel approach, the standard deviation of TAWSS within the vessel was analyzed with the staining results and pathological features. Since the onset of atherosclerosis cannot be explained by a single factor, the aim was to find the correlation between the thickness of atherosclerotic plaques and inflammatory factors through standard deviation analysis. As a result, the gap between low WSS and high WSS widened as the interval between weeks in the atherosclerosis mouse model increased. This finding not only linked the occurrence of atherosclerosis to WSS differences but also provided a connection to the causes of vulnerable plaques.
机构:
Stanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
LaDisa, John F., Jr.
Olson, Lars E.
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Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Olson, Lars E.
Hettrick, Douglas A.
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机构:
Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Hettrick, Douglas A.
Warltier, David C.
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Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Med Coll Wisconsin, Dept Med, Div Cardiovasc Dis, Milwaukee, WI 53226 USA
Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA
Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Warltier, David C.
Kersten, Judy R.
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机构:
Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Kersten, Judy R.
Pagel, Paul S.
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机构:
Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
机构:
Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Kojima, Keisuke
Hiro, Takafumi
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Hiro, Takafumi
Koyama, Yutaka
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Koyama, Yutaka
Ohgaku, Akihito
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Ohgaku, Akihito
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Fujito, Hidesato
Ebuchi, Yasunari
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Ebuchi, Yasunari
Arai, Riku
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Arai, Riku
Monden, Masaki
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Monden, Masaki
Migita, Suguru
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Migita, Suguru
Morikawa, Tomoyuki
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Morikawa, Tomoyuki
Tamaki, Takehiro
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Tamaki, Takehiro
Murata, Nobuhiro
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Murata, Nobuhiro
Akutsu, Naotaka
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Akutsu, Naotaka
Nishida, Toshihiko
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Nishida, Toshihiko
Kitano, Daisuke
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Kitano, Daisuke
Sudo, Mitsumasa
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Sudo, Mitsumasa
Fukamachi, Daisuke
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Fukamachi, Daisuke
Yoda, Shunichi
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Yoda, Shunichi
Takayama, Tadateru
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Nihon Univ, Dept Med, Div Gen Med, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Takayama, Tadateru
Hirayama, Atsushi
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机构:
Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Osaka Police Hosp, Dept Cardiol, Osaka, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan
Hirayama, Atsushi
Okumura, Yasuo
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Nihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, JapanNihon Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan