Prevalence of chromosomal abnormalities detected by fluorescence in situ hybridization in patients with chronic lymphocytic leukemia at Alexandria Main University Hospital

被引:0
|
作者
Sorour, Amani F. [1 ]
Imbaby, Salma A. E. [1 ]
Tawfik, Nourane [1 ]
机构
[1] Alexandria Univ, Fac Med, Dept Clin Pathol, Alexandria, Egypt
来源
EGYPTIAN JOURNAL OF HAEMATOLOGY | 2023年 / 48卷 / 03期
关键词
chromosomal aberrations; chronic lymphocytic leukemia; fluorescence in situ hybridization; prevalence; TP53; deletion; CYTOGENETIC ABNORMALITIES; DIAGNOSIS;
D O I
10.4103/ejh.ejh_51_22
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundUnderstanding the genetic basis of chronic lymphocytic leukemia (CLL) will help in risk stratification and a better therapeutic strategy. We aimed to evaluate the frequency of chromosomal abnormalities using fluorescence in situ hybridization (FISH) panel at our institution compared with other studies.Patients and methods and resultsA CLL FISH panel that included P53/ATM Probe Combination and D13S319/13qter/12cen Deletion Enumeration Probe was analyzed in 100 newly diagnosed patients with CLL. TP53 deletion was the most prevalent aberration, which is in contrast with other Middle Eastern countries, where deletion 13q14 was the commonest aberration among patients.ConclusionThe heterogeneity of CLL clinical course is possibly explained by underlying molecular factors that affect prognosis including data from FISH probes. It is proposed that these abnormalities should be investigated at the time of diagnosis to better understand the disease outcome and prognosis.
引用
收藏
页码:239 / 245
页数:7
相关论文
共 50 条
  • [41] Characterizing patients with multiple chromosomal aberrations detected by FISH in chronic lymphocytic leukemia
    Gonzalez-Gascon y Marin, Isabel
    Hernandez-Sanchez, Maria
    Eugenia Rodriguez-Vicente, Ana
    Puiggros, Anna
    Collado, Rosa
    Luno, Elisa
    Gonzalez, Teresa
    Ruiz-Xiville, Neus
    Ortega, Margarita
    Gimeno, Eva
    Munoz, Carolina
    Stefania Infante, Maria
    Delgado, Julio
    Teresa Vargas, Maria
    Gonzalez, Marcos
    Bosch, Francesc
    Espinet, Blanca
    Maria Hernandez-Rivas, Jesus
    Angel Hernandez, Jose
    LEUKEMIA & LYMPHOMA, 2018, 59 (03) : 633 - 642
  • [42] Chromosomal abnormalities by conventional cytogenetics and interphase fluorescence in situ hybridization in chronic lymphocytic leukemia in Taiwan, an area with low incidence—clinical implication and comparison between the West and the East
    Shang-Ju Wu
    Chien-Ting Lin
    Sheng-Yi Huang
    Fen-Yu Lee
    Ming-Chi Liu
    Hsin-An Hou
    Chien-Yuan Chen
    Bor-Sheng Ko
    Wen-Chien Chou
    Ming Yao
    Jih-Luh Tang
    Woei Tsay
    Hwei-Fang Tien
    Annals of Hematology, 2013, 92 : 799 - 806
  • [43] TRISOMY-12 IN CHRONIC LYMPHOCYTIC-LEUKEMIA DETECTED BY FLUORESCENCE IN-SITU HYBRIDIZATION - ANALYSIS BY STAGE, IMMUNOPHENOTYPE, AND MORPHOLOGY
    QUE, TH
    MARCO, JG
    ELLIS, J
    MATUTES, E
    BABAPULLE, VB
    BOYLE, S
    CATOVSKY, D
    BLOOD, 1993, 82 (02) : 571 - 575
  • [44] p53 deletion in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: Association with advanced disease and resistance to chemotherapy
    Cano, I
    Martinez, J
    Quevedo, E
    Pinilla, J
    MartinRecio, A
    Castaneda, A
    Lopez, R
    Rodriguez, A
    PerezPino, T
    HernandezNavarro, F
    BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 : 742 - 742
  • [45] Fluorescence in situ Hybridization (FISH) Aberrations and Complex Karyotype in Chronic Lymphocytic Leukemia (CLL)
    Heerema, N. A.
    Muthusamy, N.
    Ruppert, A. S.
    Andritsos, L. A.
    Grever, M. R.
    Jones, J. A.
    Breidenbach, H.
    Maddocks, K. J.
    Byrd, J. C.
    CYTOGENETIC AND GENOME RESEARCH, 2014, 142 (03)
  • [46] Clonal evolution in chronic lymphocytic leukemia studied by interphase fluorescence in-situ hybridization
    Berkova, A.
    Zemanova, Z.
    Trneny, M.
    Schwarz, J.
    Karban, J.
    Cmunt, E.
    Pavlistova, L.
    Brezinova, J.
    Michalova, K.
    NEOPLASMA, 2009, 56 (05) : 455 - 458
  • [47] Cytogenetic Abnormalities in the Spleen Detected by FISH in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
    Norin, S.
    Wallblom, A.
    Sander, B.
    Kimby, E.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S649 - S649
  • [48] Chromosome abnormalities in B-cell chronic lymphocitic leukemia detected by interphase fluorescence in situ hybridization: Correlation with biological features
    Zaccaria, A.
    Cipriani, R.
    Fagioli, M. F.
    Poletti, G.
    Giannini, B.
    Tonelli, M.
    Valenti, A. M.
    Zinzani, P. L.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 113 - 114
  • [49] ASSOCIATION BETWEEN CHROMOSOMAL ABNORMALITIES DETECTED BY FISH AND ATYPICAL CELL MORPHOLOGY FEATURES IN CHRONIC LYMPHOCYTIC LEUKEMIA
    Wawrzyniak, E.
    Palacz, A.
    Blonski, J. Z.
    Robak, T.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 534 - 534
  • [50] Molecular cytogenetic abnormalities in patients with concurrent chronic lymphocytic leukemia and multiple myeloma shown by interphase fluorescence in situ hybridization: evidence of distinct clonal origin
    Chang, H
    Wechalekar, A
    Li, L
    Reece, D
    CANCER GENETICS AND CYTOGENETICS, 2004, 148 (01) : 44 - 48