Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

被引：7

作者：

Wang, Lawrence T. ^{[1
,2
,3
,4
,5
]}

Cooper, Andrew J. R. ^{[1
]}

Farrell, Brendan ^{[3
,5
]}

Miura, Kazutoyo ^{[6
]}

Diouf, Ababacar ^{[6
]}

Muller-Sienerth, Nicole ^{[7
]}

Crosnier, Cecile ^{[8
]}

Purser, Lauren ^{[1
,16
]}

Kirtley, Payton J. ^{[9
]}

Maciuszek, Maciej ^{[3
]}

Barrett, Jordan R. ^{[3
,5
,17
]}

McHugh, Kirsty ^{[3
,5
]}

Ogwang, Rodney ^{[2
]}

Tucker, Courtney ^{[1
]}

Li, Shanping ^{[10
]}

Doumbo, Safiatou ^{[11
]}

Doumtabe, Didier ^{[11
]}

Pyo, Chul-Woo

Skinner, Jeff ^{[10
]}

Nielsen, Carolyn M. ^{[3
,5
]}

Silk, Sarah E. ^{[3
,5
]}

Kayentao, Kassoum ^{[11
]}

Ongoiba, Aissata ^{[11
]}

Zhao, Ming ^{[13
]}

Nguyen, Doan C. ^{[14
]}

Lee, F. Eun-Hyung ^{[14
]}

Minassian, Angela M. ^{[3
,5
,15
]}

Geraghty, Daniel E. ^{[12
]}

Traore, Boubacar ^{[11
]}

Seder, Robert A. ^{[2
]}

Wilder, Brandon K. ^{[9
]}

Crompton, Peter D. ^{[10
]}

Wright, Gavin J.

Long, Carole A.

Draper, Simon J. ^{[3
,5
,15
]}

Higgins, Matthew K. ^{[3
,5
]}

Tan, Joshua ^{[1
]}

机构：

[1] NIH, NIAID, Lab Immunogenet, Antibody Biol Unit, Rockville, MD 20852 USA

[2] NIH, NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA

[3] Univ Oxford, Dept Biochem, South Parks Rd, Oxford OX1 3QU, England

[4] Univ Calif San Diego, Sch Med, Med Scientist Training Program, La Jolla, CA 92093 USA

[5] Univ Oxford, Kavli Inst Nanosci Discovery, Dorothy Crowfoot Hodgkin Bldg,South Parks Rd, Oxford OX1 3QU, England

[6] NIH, NIAID, Lab Malaria & Vector Res, Rockville, MD USA

[7] Wellcome Sanger Inst, Cambridge CB10 1SA, England

[8] Univ York, Hull York Med Sch, York Biomed Res Inst, Dept Biol, York YO10 5DD, England

[9] Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97006 USA

[10] NIH, NIAID, Malaria Infect Biol & Immun Sect, Lab Immunogenet, Rockville, MD 20852 USA

[11] Univ Sci Tech & Technol Bamako, Mali Int Ctr Excellence Res, Point G,BP 1805, Bamako, Mali

[12] Fred Hutchinson Canc Res Ctr, Clin Res Div, Seattle, WA 98109 USA

[13] NIH, NIAID, Prot Chem Sect, Res Technol Branch, Rockville, MD USA

[14] Emory Univ, Div Pulm Allergy Crit Care & Sleep Med, Atlanta, GA 30322 USA

[15] NIHR Oxford Biomed Res Ctr, Oxford OX3 9DU, England

[16] MilliporeSigma, 400 Summit Dr, Burlington, MA 01803 USA

[17] Scripps Res, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA

来源：

CELL | 2024年 / 187卷 / 18期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

Highlights; specific B cells; HUMAN MONOCLONAL-ANTIBODIES; VACCINE; INVASION; TARGETS; BASIGIN; GROWTH;

D O I：

10.1016/j.cell.2024.06.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is the most advanced blood-stage malaria vaccine candidate and is being evaluated for efficacy in endemic regions, emphasizing the need to study the underlying antibody response to RH5 during natural infection, which could augment or counteract responses to vaccination. Here, we found that RH5-reactive B cells were rare, and circulating immunoglobulin G (IgG) responses to RH5 were short-lived in malaria-exposed Malian individuals, despite repeated infections over multiple years. RH5-specific monoclonal antibodies isolated from eight malaria-exposed individuals mostly targeted non-neutralizing epitopes, in contrast to antibodies isolated from five RH5-vaccinated, malaria-naive UK individuals. However, MAD8-151 and MAD8-502, isolated from two malaria-exposed Malian individuals, were among the most potent neutralizers out of 186 antibodies from both cohorts and targeted the same epitopes as the most potent vaccine-induced antibodies. These results suggest that natural malaria infection may boost RH5-vaccine-induced responses and provide a clear strategy for the development of next-generation RH5 vaccines.

引用

页数：30

共 29 条

[21] The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals
Marco Tamborrini
Anja Schäfer
Julia Hauser
Linghui Zou
Daniel H. Paris
Gerd Pluschke
Malaria Journal, 22
[22] High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion (vol 70, pg 4471, 2002)
Kocken, CHM
Withers-Martinez, C
Dubbeld, MA
van der Wel, A
Hackett, F
Valderrama, A
Blackman, MJ
Thomas, AW
INFECTION AND IMMUNITY, 2002, 70 (10) : 5901 - 5901
[23] Analysis of Fcgamma receptor IIa (cd32) gene polymorphism and anti-malarial IgG subclass antibodies to asexual blood-stage antigen of Plasmodium falciparum in an unstable malaria endemic area of Iran
Zakeri, Sedigheh
Mashhadi, Rahil
Mehrizi, Akram Abouie
Djadid, Navid Dinparast
EXPERIMENTAL PARASITOLOGY, 2013, 134 (01) : 115 - 121
[24] Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01
Payne, Ruth O.
Milne, Kathryn H.
Elias, Sean C.
Edwards, Nick J.
Douglas, Alexander D.
Brown, Rebecca E.
Silk, Sarah E.
Biswas, Sumi
Miura, Kazutoyo
Roberts, Rachel
Rampling, Thomas W.
Venkatraman, Navin
Hodgson, Susanne H.
Labbe, Genevieve M.
Halstead, Fenella D.
Poulton, Ian D.
Nugent, Fay L.
de Graaf, Hans
Sukhtankar, Priya
Williams, Nicola C.
Ockenhouse, Christian F.
Kathcart, April K.
Qabar, Aziz N.
Waters, Norman C.
Soisson, Lorraine A.
Birkett, Ashley J.
Cooke, Graham S.
Faust, Saul N.
Woods, Colleen
Ivinson, Karen
McCarthy, James S.
Diggs, Carter L.
Vekemans, Johan
Long, Carole A.
Hill, Adrian V. S.
Lawrie, Alison M.
Dutta, Sheetij
Draper, Simon J.
JOURNAL OF INFECTIOUS DISEASES, 2016, 213 (11): : 1743 - 1751
[25] MALARIA DIAGNOSIS - IDENTIFICATION OF AN ANTI-40-KDA POLYPEPTIDE ANTIBODY-RESPONSE ASSOCIATED WITH ACTIVE OR RECENT INFECTION AND STUDY OF THE IGG/IGM RATIO OF ANTIBODIES TO BLOOD-STAGE PLASMODIUM-FALCIPARUM ANTIGENS
BALTHAZARGUEDES, HC
FERREIRADACRUZ, MF
MONTENEGROJAMES, S
DANIELRIBEIRO, CT
PARASITOLOGY RESEARCH, 1995, 81 (04): : 305 - 309
[26] Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candiate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRpm2 Does Not Improve the In Vitro Efficacy
Spiegel, Holger
Boes, Alexander
Fendel, Rolf
Reimann, Andreas
Schillberg, Stefan
Fischer, Rainer
FRONTIERS IN IMMUNOLOGY, 2017, 8
[27] Breakthrough infection elicits hypermutated IGHV3-53/3-66 public antibodies with broad and potent neutralizing activity against SARS-CoV-2 variants including the emerging EG.5 lineages
Li, Ling
Chen, Xixian
Wang, Zuowei
Li, Yunjian
Wang, Chen
Jiang, Liwei
Zuo, Teng
PLOS PATHOGENS, 2023, 19 (12)
[28] Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01 (vol 213, pg 1743, 2016)
Payne
JOURNAL OF INFECTIOUS DISEASES, 2016, 214 (06): : 978 - 978
[29] Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-119) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa
John, CC
O'Donnell, RA
Sumba, PO
Moormann, AM
de Koning-Ward, TF
King, CL
Kazura, JW
Crabb, BS
JOURNAL OF IMMUNOLOGY, 2004, 173 (01): : 666 - 672

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