Background: The COVID-19 pandemic was marked by an infodemic, characterized by the rapid spread of both accurate andfalse information, which significantly affected public health. This infodemic led to confusion, mistrust in health authorities,noncompliance with health guidelines, and engagement in risky health behaviors. Understanding the dynamics of misinformationduring the pandemic is crucial for developing effective public health communication strategies.Objective: This comprehensive analysis aimed to examine the complexities of COVID-19 misinformation. Specifically, itsought to identify the sources and themes of misinformation, the target audiences most affected, and the effectiveness of variouspublic health communication strategies in mitigating misinformation.Methods: This scoping review used the MEDLINE (PubMed), Embase, and Scopus databases to identify relevant studies. Anestablished, methodical framework for scoping reviews was used to review literature published between December 2019 andSeptember 2023. The inclusion criteria focused on peer-reviewed studies published in English that address COVID-19misinformation and its sources, themes, and target audiences, as well as the effectiveness of public health communicationstrategies.Results: The scoping review identified that misinformation significantly impacted mental health, vaccine hesitancy, and healthcare decision-making. Social media and traditional media were major conduits for spreading misinformation. Key misinformationthemes included the origins of the virus, ineffective treatments, and misunderstandings about public health measures. Misinformationsources ranged from social media platforms to traditional media outlets and informal networks. The impact of misinformationwas found to vary across different regions and demographic groups, with vulnerable populations being disproportionately affected.Effective strategies to counter misinformation included enhancing health literacy; using digital technology; promoting clear,authoritative communication; and implementing fact-checking mechanisms. In addition, community engagement and targetedhealth campaigns played a crucial role in addressing misinformation.Conclusions: The review emphasizes the critical need for accurate and consistent messaging to combat misinformation.Cooperative efforts among policy makers, health professionals, and communication experts are essential for developing effectiveinterventions. Addressing the infodemic is vital for building a well-informed, health-literate society capable of handlingmisinformation in future global health crises. The study provides valuable insights into the dynamics of misinformation andhighlights the importance of robust public health communication strategies. These findings can guide future efforts to mitigatethe impact of misinformation during health emergencies