Synthesis of new polyazomethine-based pyrazole moieties as promising biologically active macromolecules

Using the polycondensation technique, it was possible to synthesize a new class of biologically active polyazomethine based on pyrazole moiety. The polymerization occurred through the interaction between terephthalaldehyde and various derivatives of diaminopyrazole. The polymers that were made were given the letters PAZm/Py1-4 to reflect the different diaminopyrazole derivatives that were used. The monomer and polymer structures were investigated by common spectral characterization methods. The new PAZm/Py1-4 were examined by gel permeation chromatography (GPC), solubility tests, thermogravimetric analysis (TGA), X-ray diffraction analysis (XRD), and scanning electron microscopy (SEM). The newly synthesized polymers have high thermal stability and normal crystalline behavior. The antibacterial properties of all synthesized polymers were evaluated against the Gram-positive bacteria and the Gram-negative bacteria. Additionally, two types of fungi were used to test how well the prepared polymers worked against fungi. PAZm/Py1 and PAZm/Py4 showed slight antibacterial activity against the representative Gram-positive bacteria, while PAZm/Py2 and PAZm/Py3 had no significant influence. All the tested polymers showed slight to moderate antibacterial activity against the representative Gram-negative bacteria. PAZm/Py1 and PAZm/Py4 had a greater antifungal influence than other polymers.