Design, Synthesis, Molecular Docking, and in vitro Cytotoxicity Studies of Marine Natural Product Herdmanine Derivatives as Multitarget Inhibitor for EGFR and HER2 Breast Cancer Proteins

被引：0

作者：

Gunjan, Pradeep ^{[1
]}

Ganjoo, Samarth ^{[1
]}

Kumar, Pradeep ^{[1
]}

Goel, Nikita ^{[1
]}

Yadav, Monika ^{[2
]}

Verma, Anita Kamra ^{[2
,3
]}

Bhagat, Sunita ^{[1
,3
]}

机构：

[1] Univ Delhi, ARSD Coll, Dept Chem, Organ Synth Res Lab, Delhi 110021, India

[2] Univ Delhi, Kirori Mal Coll, Dept Zool, Nanobiotech Lab, Delhi 110007, India

[3] Univ Delhi, Delhi Sch Publ Hlth, Inst Eminence, Delhi 110007, India

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 34期

关键词：

Anti-cancer; 1; Natural product 2; Molecular docking 3; Indoles; 4; Cytotoxicity; 5; EXPRESSION; ANALOGS;

D O I：

10.1002/slct.202401308

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Breast cancer is a potentially deadly disease that affects millions of individuals worldwide. Therefore, it is crucial to design highly targeted therapeutic techniques with low toxicity. In this work, we synthesized natural product Herdmanine's ester derivatives and tested them against EGFR and HER2 proteins as multitargated inhibitor of breast cancer progression. Further, the newly synthesized compounds were evaluated for cytotoxicity against breast cancer cell lines MCF-7, MDA-MB-231 and MDA-MB-157 and the biocompatibility towards NIH 3T3 cells. Higher toxicity and positive viability profiles of Herdmanine derivatives indicate their potential use for further exploration in breast cancer application.

引用

页数：8

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