Post-translational modification in the pathogenesis of vitiligo

被引：1

作者：

Lu, Lu ^{[1
]}

He, Huimin ^{[1
]}

Feng, Jindi ^{[1
]}

Hu, Zhonghui ^{[1
]}

Zhang, Shiyu ^{[1
]}

Yang, Lu ^{[1
]}

Liu, Yuehua ^{[1
]}

Wang, Tao ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Dermatol, State Key Lab Complex Severe & Rare Dis,Natl Clin, Beijing, Peoples R China

来源：

IMMUNOLOGIC RESEARCH | 2024年

关键词：

Vitiligo; Post-translational modification; Pathogenesis; Therapeutics; MELANOCYTE DEGENERATION; MAPK PATHWAYS; T-CELLS; ACTIVATION; PROTEIN; PHOSPHORYLATION; KERATINOCYTES; EXPRESSION; AZATHIOPRINE; SUMOYLATION;

D O I：

10.1007/s12026-024-09545-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitiligo is a chronic dermatological condition marked by the loss of skin pigmentation. Its complex etiology involves multiple factors and has not been completely elucidated. Protein post-translational modification pathways have been proven to play a significant role in inflammatory skin diseases, yet research in the context of vitiligo remains limited. This review focuses on the role of post-translational modifications in vitiligo pathogenesis, especially their impact on cellular signaling pathways related to immune response and melanocyte survival. Current therapeutic strategies targeting these pathways are discussed, emphasizing the potential for novel treatments in vitiligo management.

引用

页码：1229 / 1237

页数：9

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