Is Phenobarbital an Effective Treatment for Alcohol Withdrawal Syndrome?

被引：0

作者：

Long, Brit ^{[1
]}

Keim, Samuel M. ^{[2
]}

Gottlieb, Michael ^{[3
]}

Rathlev, Niels ^{[4
]}

机构：

[1] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX, Mexico

[2] Univ Arizona, Dept Emergency Med, Tucson, AZ 85724 USA

[3] Rush Univ, Dept Emergency Med, Med Ctr, Chicago, IL USA

[4] Univ Massachusetts, Dept Emergency Med, Chan Med Sch Baystate, Springfield, MA USA

来源：

JOURNAL OF EMERGENCY MEDICINE | 2024年 / 67卷 / 05期

关键词：

drawal syndrome; phenobarbital; benzodiazepines; GABA; admission. He denies recent trauma; chest pain; shortness; EMERGENCY-DEPARTMENT VISITS; MANAGEMENT;

D O I：

10.1016/j.jemermed.2024.05.007

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Alcohol use disorder is associated with a variety of complications, including alcohol withdrawal syndrome (AWS), which may occur in those who decrease or stop alcohol consumption suddenly. AWS is associated with a range of signs and symptoms, which are most commonly treated with GABAergic medications. Clinical Question: Is phenobarbital an effective treatment for AWS? Evidence Review: Studies retrieved included two prospective, randomized, double-blind studies and three systematic reviews. These studies provided estimates of the effectiveness and safety of phenobarbital for treatment of AWS. Conclusions: Based on the available literature, phenobarbital is reasonable to consider for treatment of AWS. Clinicians must consider the individual patient, clinical situation, and comorbidities when selecting a medication for treatment of AWS. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

引用

页码：e494 / e503

页数：10

共 50 条

[21] The Effect of Phenobarbital on Excitatory Transmission in Alcohol Withdrawal Syndrome Reply
Gottlieb, Michael
Chien, Nicholas
Long, Brit
ANNALS OF EMERGENCY MEDICINE, 2024, 84 (03) : 328 - 329
[22] PHENOBARBITAL MONOTHERAPY FOR ACUTE ALCOHOL WITHDRAWAL SYNDROME IN THE SURGICAL ICU
Thompson, Molly
Irwin, Madison
Murphy, Claire
CRITICAL CARE MEDICINE, 2019, 47
[23] EVALUATION OF PHENOBARBITAL DOSING IN HOSPITALIZED PATIENTS WITH ALCOHOL WITHDRAWAL SYNDROME
Stallworth, Sara
Stilley, Kelsey
Viriyakitja, Wassamon
Powers, Shelby
Parish, Alice
Erkanli, Alaattin
Komisar, Jonathan
CRITICAL CARE MEDICINE, 2024, 52
[24] COMPARISON OF TWO DOSING STRATEGIES OF PHENOBARBITAL FOR ALCOHOL WITHDRAWAL SYNDROME
Elsamadisi, Pansy
Adler, Alexandra
Wong, Adrian
Hayes, Margaret
Hsu, Douglas
Eche, Mary
CRITICAL CARE MEDICINE, 2021, 49 (01) : 25 - 25
[25] STANDARDIZING PHENOBARBITAL USE IN ALCOHOL WITHDRAWAL SYNDROME FOR A MULTIHOSPITAL SYSTEM
Nevinski, Lauren
Matthews, Emily
CRITICAL CARE MEDICINE, 2023, 51 (01) : 384 - 384
[26] Treatment of Alcohol Withdrawal Syndrome
DeSimone, Edward
Tilleman, Jennifer
Powell, Trenton
US PHARMACIST, 2014, 39 (11) : 38 - 41
[27] TREATMENT FOR ALCOHOL WITHDRAWAL SYNDROME
KOBERNICK, M
ANNALS OF EMERGENCY MEDICINE, 1983, 12 (05) : 329 - 329
[28] TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME
BOECKH, E
FORTSCHRITTE DER MEDIZIN, 1980, 98 (12) : 444 - 450
[29] Treatment of Alcohol Withdrawal Syndrome with Benzodiazepines or Phenobarbital in the Medical Intensive Care Unit, a Retrospective Comparison
Saukkonen, J. J.
Mekuria, T.
Ronan, M.
Connell, G.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
[30] In Reply to "Treatment of Alcohol Withdrawal Syndrome: Phenobarbital vs CIWA-Ar Protocol" Response
Tidwell, William P.
Thomas, Tonya L.
Pouliot, Jonathon D.
Canonico, Angelo E.
Webber, Angus J.
AMERICAN JOURNAL OF CRITICAL CARE, 2019, 28 (02) : 98 - 99

← 1 2 3 4 5 →