One-Flask Synthesis of Cyclic Diguanosine Monophosphate (c-di-GMP)

被引：0
|
作者：
Gaffney, Barbara L. [1 ]
Jones, Roger A. [1 ]
机构：
[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA
来源：
CURRENT PROTOCOLS | 2023年 / 3卷 / 04期
基金：
美国国家卫生研究院;
关键词：
bacterial signaling; c-di-GMP; chemical synthesis; STRUCTURAL BASIS; BINDING; LIGAND; AMP; RECOGNITION; DIGUANYLATE;
D O I：
10.1002/cpz1.740
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) plays a key role in controlling biofilm formation and pathogenic virulence, among many other functions. It has widespread consequences for human health, and current research is actively exploring its molecular mechanisms. The convenient one-flask, gram-scale synthesis of c-di-GMP described here has facilitated these efforts and has been applied to a variety of analogs. (c) 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.
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页数：8
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