One-Flask Synthesis of Cyclic Diguanosine Monophosphate (c-di-GMP)

被引：0

作者：

Gaffney, Barbara L. ^{[1
]}

Jones, Roger A. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

CURRENT PROTOCOLS | 2023年 / 3卷 / 04期

基金：

美国国家卫生研究院;

关键词：

bacterial signaling; c-di-GMP; chemical synthesis; STRUCTURAL BASIS; BINDING; LIGAND; AMP; RECOGNITION; DIGUANYLATE;

D O I：

10.1002/cpz1.740

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The bacterial signaling molecule cyclic diguanosine monophosphate (c-di-GMP) plays a key role in controlling biofilm formation and pathogenic virulence, among many other functions. It has widespread consequences for human health, and current research is actively exploring its molecular mechanisms. The convenient one-flask, gram-scale synthesis of c-di-GMP described here has facilitated these efforts and has been applied to a variety of analogs. (c) 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.

引用

页数：8

共 50 条

[1] One-Flask Syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] Thiophosphate Analogues
Gaffney, Barbara L.
Veliath, Elizabeth
Zhao, Jianwei
Jones, Roger A.
ORGANIC LETTERS, 2010, 12 (14) : 3269 - 3271
[2] The Characterization of a Cyclic-Di-GMP (c-Di-GMP) Pathway Leads to a New Tool for Studying c-Di-GMP Metabolic Genes
Tamayo, Rita
JOURNAL OF BACTERIOLOGY, 2013, 195 (21) : 4779 - 4781
[3] Optogenetic Manipulation of Cyclic Di-GMP (c-di-GMP) Levels Reveals the Role of c-di-GMP in Regulating Aerotaxis Receptor Activity in Azospirillum brasilense
O'Neal, Lindsey
Ryu, Min-Hyung
Gomelsky, Mark
Alexandre, Gladys
JOURNAL OF BACTERIOLOGY, 2017, 199 (18)
[4] Synthesis of cyclic bis(3′-5′)diguanylic acid (c-di-GMP) analogs
Hyodo, M
Sato, Y
Hayakawa, Y
TETRAHEDRON, 2006, 62 (13) : 3089 - 3094
[5] Quantification of cyanobacterial cyclic di-guanosine monophosphate (c-di-GMP) by liquid chromatography electrospray ionization tandem mass spectrometry
Kameda, Marina
Kanaly, Robert A.
Harada, Mei
Aoki, Setsuyuki
Tukada, Hideyuki
Kutsuna, Shinsuke
JOURNAL OF MICROBIOLOGICAL METHODS, 2022, 196
[6] SYNTHESIS AND CHARACTERIZATION OF C8 ANALOGS OF c-di-GMP
Veliath, Elizabeth
Kim, Seho
Gaffney, Barbara L.
Jones, Roger A.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2011, 30 (11): : 961 - 978
[7] New approach for the synthesis of c-di-GMP and its analogues
Amiot, Nicolas
Heintz, Karine
Giese, Bernd
SYNTHESIS-STUTTGART, 2006, (24): : 4230 - 4236
[8] One-flask synthesis of porphyrin metal complexes
Manda, Amaravathi
Maradolla, Mohan Babu
Garimella, Chandramouli
Lingamallu, Giribabu
JOURNAL OF CHEMICAL RESEARCH, 2007, (07) : 390 - 391
[9] Cyclic Di-GMP (c-Di-GMP) Goes into Host Cells-c-Di-GMP Signaling in the Obligate Intracellular Pathogen Anaplasma phagocytophilum
Romling, Ute
JOURNAL OF BACTERIOLOGY, 2009, 191 (03) : 683 - 686
[10] Differential binding of 2′-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins
Luo, Yiling
Zhou, Jie
Watt, Sarah K.
Lee, Vincent T.
Dayie, T. Kwaku
Sintim, Herman O.
MOLECULAR BIOSYSTEMS, 2012, 8 (03) : 772 - 778

← 1 2 3 4 5 →