Phthalated cashew gum-based polyelectrolyte complex for oral insulin delivery

被引：2

作者：

Bezerra, Janira Maria Nascimento Alves ^{[1
]}

Oliveira, Antonia Carla de Jesus ^{[1
]}

Leao, Amanda Damasceno ^{[1
]}

Ribeiro, Fabio de Oliveira Silva ^{[2
]}

Borba, Elizabeth Fernanda de Oliveira ^{[3
]}

Hallwass, Fernando ^{[4
]}

da Silva, Teresinha Gonsalves ^{[3
]}

da Silva, Durcilene Alves ^{[2
]}

Rolim-Neto, Pedro Jose ^{[5
]}

Silva-Filho, Edson C. ^{[6
]}

Soares, Monica Felts de La Roca ^{[1
]}

Soares-Sobrinho, Jose Lamartine ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Pharmaceut Sci, Qual Control Core Med & Correlates NCQMC, Recife, PE, Brazil

[2] Fed Univ Delta Parnaiba, Res Ctr Biodivers & Biotechnol BIOTEC, Parnaiba, PI, Brazil

[3] Fed Univ Pernambuco UFPE, Dept Pharmaceut Sci, Recife, Brazil

[4] Univ Fed Pernambuco, Dept Fundamental Chem, Recife, PE, Brazil

[5] Univ Fed Pernambuco, Lab Technol Med LTM, Recife, Brazil

[6] Univ Fed Piaui, Interdisciplinary Lab Adv Mat LIMAV, Teresina, PI, Brazil

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2024年 / 100卷

关键词：

Natural polysaccharides; Chemical modification; Nanostructured systems; CHITOSAN PHTHALATE; DRUG-DELIVERY; IN-VITRO; VIVO EVALUATION; NANOPARTICLES; MICROSPHERES; SYSTEMS; DESIGN;

D O I：

10.1016/j.jddst.2024.106015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cashew gum (CG) is a biopolymer that can be modified with phthalic groups through microwave irradiation (MW). This study highlights the versatility of CG and its ability to be modified to improve its drug delivery characteristics. Phthalated cashew gum (PCG) was characterized by various instrumental techniques. Nanoparticles obtained by the PCG and chitosan (CH) polyelectrolyte complexation technique were produced for oral insulin administration. The developed nanosystems had an average size of 390 nm, polydispersion index 0.04 and zeta potential of 15.4 mV, encapsulation efficiency of 77.5 %. Insulin release in the simulated gastric and intestinal environments maintained sustained release. Cytotoxicity studies demonstrated that PCG, CH and the system produced exhibited relatively low cytotoxicity. Taken together, the modification capability of CG and its ability to form nanoparticles with CH is an effective strategy to develop nanovehicles for enhanced oral insulin delivery.

引用

页数：8

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