Evaluating the efficacy of immunotherapy in gastric cancer: Insights from immune checkpoint inhibitors

被引:0
|
作者
Yang, Yu-Nuo [1 ]
Wang, Li-Sheng [2 ]
Dang, Yan-Qi [1 ]
Ji, Guang [1 ]
机构
[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, China Canada Ctr Res Digest Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China
[2] Univ Ottawa, Dept Biochem, Ottawa, ON K1H 8M5, Canada
关键词
Gastric cancer; Immune checkpoint inhibitors; Sarcopenia; Myosteatosis; Prediction model;
D O I
10.3748/wjg.v30.i32.3726
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The emergence of immunotherapy, particularly immune checkpoint inhibitors (ICIs), represents a groundbreaking approach to treating gastric cancer (GC). However, the prognosis of GC patients receiving ICI treatment is influenced by various factors. This manuscript identified sarcopenia and myosteatosis as inde-pendent prognostic factors impacting the outcomes of GC patients treated with ICIs. Additionally, this study introduced a visual predictive model to estimate the prognosis of GC patients. If confirmed by further studies, this observation could provide valuable insights to propel the advancement of personalized clinical medicine and the integration of precision medicine practices.
引用
收藏
页数:5
相关论文
共 50 条
  • [41] Association of gastric acid suppression with efficacy of immune checkpoint inhibitors (ICIs) in advanced cancer patients
    Izawa, Naoki
    Shiokawa, Hisae
    Onuki, Risa
    Hamaji, Koki
    Furuya, Naoki
    Ohashi, Hiroyuki
    Nishi, Tomohiro
    Kasugai, Shigeru
    Arai, Hiroyuki
    Doi, Ayako
    Horie, Yoshiki
    Hirakawa, Mami
    Mizukami, Takuro
    Ogura, Takashi
    Tsuda, Takashi
    Sunakawa, Yu
    Nakajima, Takako
    ANNALS OF ONCOLOGY, 2019, 30
  • [42] Alpha-fetoprotein predicts the treatment efficacy of immune checkpoint inhibitors for gastric cancer patients
    Zhang, Jingjing
    Wang, Lei
    Zhang, Shasha
    Cao, Ruijie
    Zhao, Yufei
    Zhao, Yue
    Song, Yanrong
    Guo, Zhanjun
    BMC CANCER, 2024, 24 (01)
  • [43] Application of immune checkpoint inhibitors for resectable gastric/gastroesophageal cancer
    Lin, Feizhi
    Chen, Yongming
    Huang, Bowen
    Ruan, Shenghang
    Lin, Jun
    Chen, Zewei
    Huang, Chunyu
    Zhao, Baiwei
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [44] Application of immune checkpoint inhibitors and microsatellite instability in gastric cancer
    Yan, Shi-Yan
    Fan, Jian-Gao
    WORLD JOURNAL OF GASTROENTEROLOGY, 2024, 30 (21) : 2734 - 2739
  • [45] Progress and prospects of immune checkpoint inhibitors in advanced gastric cancer
    Zeng, Zhu
    Yang, Biao
    Liao, Zhengyin
    FUTURE ONCOLOGY, 2021, 17 (12) : 1553 - 1569
  • [46] Insights on the regulation of immune checkpoint genes - potential implications for cancer immunotherapy
    Leibowitz-Amit, R.
    Layani, A.
    Dobosz, P.
    Kaner, K. Slabodnik
    Sidi, Y.
    Avni, D.
    EUROPEAN JOURNAL OF CANCER, 2018, 103 : E73 - E73
  • [47] Combining active immunotherapy and immune checkpoint inhibitors in prostate cancer.
    Singh, Harpreet
    Madan, Ravi Amrit
    Dahut, William L.
    Strauss, Julius
    Rauckhorst, Myrna
    McMahon, Sheri
    Heery, Christopher Ryan
    Schlom, Jeffrey
    Gulley, James L.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [48] Combining active immunotherapy and immune checkpoint inhibitors in prostate cancer.
    Singh, Harpreet
    Madan, Ravi Amrit
    Dahut, William L.
    Coyne, Geraldine Helen O'Sullivan
    Rauckhorst, Myrna
    McMahon, Sheri
    Heery, Christopher Ryan
    Schlom, Jeffrey
    Gulley, James L.
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (07)
  • [49] Acquired resistance for immune checkpoint inhibitors in cancer immunotherapy: challenges and prospects
    Chen, Xunrui
    Zhang, Wenhui
    Yang, Wenyan
    Zhou, Min
    Liu, Feng
    AGING-US, 2022, 14 (02): : 1048 - 1064
  • [50] Immune Checkpoint Inhibitors: Making Immunotherapy a Reality for the Treatment of Lung Cancer
    Brahmer, Julie R.
    Pardoll, Drew M.
    CANCER IMMUNOLOGY RESEARCH, 2013, 1 (02) : 85 - 91