Predictors of Cognitive Aging Profiles Over 15 Years: A Longitudinal Population-Based Study

被引:2
|
作者
Ekstrom, Ingrid [1 ]
Josefsson, Maria [2 ]
Backman, Lars [1 ]
Laukka, Erika J. [1 ,3 ]
机构
[1] Stockholm Univ, Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, S-17177 Stockholm, Sweden
[2] Umea Univ, Umea Sch Business, Dept Stat Econ & Stat, Umea, Sweden
[3] Stockholm Gerontol Res Ctr, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
cognition; cognitive aging; epidemiology; trajectories; longitudinal; OLD-AGE; DECLINE; MEMORY; DEMENTIA; ADULTS; RISK; LIFE; COHORT; TRAJECTORIES; METAANALYSIS;
D O I
10.1037/pag0000807
中图分类号
R4 [临床医学]; R592 [老年病学];
学科分类号
1002 ; 100203 ; 100602 ;
摘要
The present study aimed to characterize profiles fi les of cognitive aging and how these can be predicted from interindividual differences in demographic, lifestyle, health, and genetic factors. The participants were 1,966 older adults (mean baseline age = 71.6 years; 62.9% female), free from dementia at baseline and with at least two cognitive assessments over the 15-year follow-up, from the population-based Swedish National Study on Aging and Care in Kungsholmen. The cognitive assessment comprised tests of semantic and episodic memory, letter and category fl uency, perceptual speed, and executive function. First, we estimated the level and change within each of the cognitive domains with linear mixed effect models, based on which we grouped our sample into participants with " maintained high cognition," " " moderate cognitive decline," " or " accelerated cognitive decline." " Second, we analyzed determinants of group membership within each cognitive domain with multinomial logistic regression. Third, group memberships within each cognitive domain were used to derive general cognitive aging profiles fi les with latent class analysis. Fourth, the determinants of these profile fi le memberships were analyzed with multinomial logistic regression. Follow-up analyses targeted profiles fi les and predictors specifically fi cally related to the rate of cognitive change. We identified fi ed three latent profiles fi les of overall cognitive performance during the follow-up period with 31.6% of the sample having maintained high cognition, 50.6% having moderate cognitive decline, and 17.8% having accelerated cognitive decline. In multiadjusted analyses, maintained high cognition was predicted by female sex, higher education, and faster walking speed. Smoking, loneliness, and being an epsilon 4 carrier were associated with a lower likelihood of maintained high cognition. Higher age, diagnosis of diabetes, depression, and carrying the apolipoprotein E epsilon 4 allele increased the likelihood of accelerated cognitive decline. Factors at baseline that could significantly fi cantly predict profile fi le membership within the specific fi c cognitive domains included age, sex, years of education, walking speed, diabetes, and the epsilon 4 allele. Of note, these factors differed across cognitive domains. In sum, we identified fi ed demographic, lifestyle, health, and genetic factors of interindividual differences in domain-specific fi c and general cognitive aging profiles, fi les, some of which are modifiable. fi able.
引用
收藏
页码:467 / 483
页数:17
相关论文
共 50 条
  • [31] Disability and post-trauma stress in the population over 15 years old in Kashan, Iran: A population-based study
    Sehat, Zahra
    Fakharian, Esmaeil
    Sehat, Mojtaba
    Omidi, Abdollah
    CHINESE JOURNAL OF TRAUMATOLOGY, 2020, 23 (06) : 351 - 355
  • [32] Disability and post-trauma stress in the population over 15 years old in Kashan, Iran: A population-based study
    Sehat Zahra
    Fakharian Esmaeil
    Sehat Mojtaba
    Omidi Abdollah
    Trauma Research Center
    Department of Neurosurgery
    Department of Clinical Psychology
    中华创伤杂志英文版, 2020, 23 (06) : 351 - 355
  • [33] Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study
    Zhou, Rong
    Wei, Shan
    Wang, Yanyu
    Gao, Ling
    Dang, Liangjun
    Shang, Suhang
    Hu, Ningwei
    Peng, Wei
    Zhao, Yi
    Yuan, Ye
    Wang, Jingyi
    Wang, Jin
    Qu, Qiumin
    BRAIN SCIENCES, 2022, 12 (12)
  • [34] Early determinants of overweight at 4.5 years in a population-based longitudinal study
    Dubois, L
    Girard, M
    INTERNATIONAL JOURNAL OF OBESITY, 2006, 30 (04) : 610 - 617
  • [35] Early determinants of overweight at 4.5 years in a population-based longitudinal study
    L Dubois
    M Girard
    International Journal of Obesity, 2006, 30 : 610 - 617
  • [36] The Relationship between Handgrip Strength and Cognitive Function in Elderly Koreans over 8 Years: A Prospective Population-Based Study Using Korean Longitudinal Study of Ageing
    Kim, Kyung Hwan
    Park, Soo Kyoung
    Lee, Dong Ryul
    Lee, Jungun
    KOREAN JOURNAL OF FAMILY MEDICINE, 2019, 40 (01): : 9 - 15
  • [37] Decline across different domains of cognitive function in normal aging: Results of a longitudinal population-based study using CAMCOG
    Cullum, S
    Huppert, FA
    McGee, M
    Dening, T
    Ahmed, A
    Paykel, ES
    Brayne, C
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2000, 15 (09) : 853 - 862
  • [38] Temporal Trends in the Prevalence of Dysphagia and Proton Pump Inhibitor Use Over 15 Years: A Population-Based Study
    Choung, Rok Seon
    Locke, Giles R.
    Schleck, Cathy D.
    Zinsmeister, Alan R.
    Katzka, David A.
    Talley, Nicholas J.
    GASTROENTEROLOGY, 2013, 144 (05) : S504 - S505
  • [39] Not working 3 years after breast cancer:: Predictors in a population-based study
    Drolet, M
    Maunsell, E
    Brisson, J
    Brisson, C
    Mâsse, B
    Deschênes, L
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (33) : 8305 - 8312
  • [40] Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging - Population-based study
    Geda, Yonas E.
    Roberts, Rosebud O.
    Knopman, David S.
    Petersen, Ronald C.
    Christianson, Teresa J. H.
    Pankratz, Vernon S.
    Smith, Glenn E.
    Boeve, Bradley F.
    Ivnik, Robert J.
    Tangalos, Eric G.
    Rocca, Walter A.
    ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (10) : 1193 - 1198