Epilepsy associated with Graves' disease: Report of two cases

被引：0
|
作者：
Nagaki, Shigeru [1 ,2 ]
Osawa, Makiko [1 ]
Nagata, Satoru [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Pediat, 8-1 Kawadachou,Shnjukukuku, Tokyo 1628666, Japan
[2] Nagaki Childrens Clin, Tokyo, Japan
来源：
SAGE OPEN MEDICAL CASE REPORTS | 2024年 / 12卷
关键词：
Epilepsy; thiamazole; levothyroxine; Graves' disease; SEIZURES; THYROXINE; SPIKE;
D O I：
10.1177/2050313X241272569
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We present two cases of epilepsy associated with Graves' disease. Case 1 is a 22-year-old woman. She had three epileptic seizures and was diagnosed with idiopathic generalized epilepsy. She was treated with valproic acid (VPA). She was later diagnosed with Graves' disease, and treated with antithyroid medication (thiamazole). We added a thyroid medication (levothyroxine) because of a decrease in free thyroxine observed with antithyroid medication. Case 2 is an 18-year-old woman. She had three epileptic seizures and was diagnosed with juvenile myoclonic epilepsy and treated with VPA. Then, she was diagnosed with Graves' disease and was treated with thiamazole. Levothyroxine was added due to low fT4 induced by thiamazole. Due to poor compliance with antithyroid medication, the thyroid functional status was not stable. Both patients became seizure-free and euthyroid after VPA and thiamazole treatments.
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页数：5
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