Roles of Mesenchymal Stem Cells in Breast Cancer Therapy: Engineered Stem Cells and Exosomal Cell-Free Based Therapy

被引：1
|
作者：
Fath, Mohsen Karami [1 ]
Zadian, Seyed Sajjad [2 ]
Torbati, Samaneh Mohammad Bagherzadeh [3 ]
Saqagandomabadi, Vahid [4 ]
Afshar, Omid Yousefi [5 ]
Khalilzad, Mohammad [6 ]
Abedi, Sara [7 ]
Moliani, Afshin [8 ]
Barati, Ghasem [9 ]
机构：
[1] Kharazmi Univ, Fac Biol Sci, Dept Cellular & Mol Biol, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Fac Med, Dept Immunol, Tehran, Iran
[3] Babol Univ Med Sci, Fac Med, Mazandaran, Iran
[4] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy
[5] Valiasr Hosp, Clin Res Dev Unit, Tabriz, Iran
[6] Tabriz Univ Med Sci, Fac Med, Tabriz, Iran
[7] Univ Tabriz, Fac Nat Sci, Tabriz, Iran
[8] Isfahan Univ Med Sci, Isfahan Med Students Res Ctr, Esfahan, Iran
[9] Stem Cell Technol Res Ctr, Tehran, Iran
来源：
CURRENT MOLECULAR MEDICINE | 2024年
关键词：
Mesenchymal stem cells; breast cancer; genetic modification; extracellular vesicle; cancer therapy; cell therapy; cell-free therapy; VERSUS-HOST-DISEASE; STROMAL CELLS; EXTRACELLULAR VESICLES; ONCOLYTIC VIROTHERAPY; TARGETED DELIVERY; GENE-THERAPY; RISK; RECEPTOR; GROWTH; LUNG;
D O I：
10.2174/0115665240274818231207054037
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Breast cancer has a high prevalence among women, with a high mortality rate. The number of people who suffer from breast cancer disease is increasing, whereas metastatic cancers are mostly incurable, and existing therapies have unfavorable side effects. For an extended duration, scientists have dedicated their efforts to exploring the potential of mesenchymal stem cells (MSCs) for the treatment of metastatic cancers, including breast cancer. MSCs could be genetically engineered to boost their anticancer potency. Furthermore, MSCs can transport oncolytic viruses, suicide genes, and anticancer medicines to tumors. Extracellular vesicles (EVs) are MSC products that have attracted scientist's attention as a cell-free treatment. This study narratively reviews the current state of knowledge on engineered MSCs and their EVs as promising treatments for breast cancer.
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页数：14
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