Bioluminescent Systems for Theranostic Applications

被引：0
|
作者：
Kim, Hyemin [1 ]
Jung, Seung Oh [1 ]
Lee, Seungchan [1 ]
Lee, Yujin [1 ]
机构：
[1] Konkuk Univ, Dept Cosmet Engn, 120 Neungdong Ro, Seoul 05029, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 14期
基金：
新加坡国家研究基金会;
关键词：
bioluminescence; luciferase; theranostics; bioimaging; biosensing; photodynamic therapy; optogenetics; DEEP-SEA SHRIMP; PROTEIN-PROTEIN INTERACTIONS; LUCIFERASE REPORTER; SENSOR PROTEINS; PHOTODYNAMIC THERAPY; GENE-EXPRESSION; IN-VITRO; DELIVERY; COELENTERAZINE; TISSUE;
D O I：
10.3390/ijms25147563
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioluminescence, the light produced by biochemical reactions involving luciferases in living organisms, has been extensively investigated for various applications. It has attracted particular interest as an internal light source for theranostic applications due to its safe and efficient characteristics that overcome the limited penetration of conventional external light sources. Recent advancements in protein engineering technologies and protein delivery platforms have expanded the application of bioluminescence to a wide range of theranostic areas, including bioimaging, biosensing, photodynamic therapy, and optogenetics. This comprehensive review presents the fundamental concepts of bioluminescence and explores its recent applications across diverse fields. Moreover, it discusses future research directions based on the current status of bioluminescent systems for further expansion of their potential.
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收藏
页数：21
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