Predicting outcomes in malignant ovarian germ cell tumors using the modified International Germ Cell Cancer Collaborative Group classification system
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作者:
Zhang, Xinyue
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Peking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R ChinaPeking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Zhang, Xinyue
[1
,2
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Yang, Jie
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Peking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R ChinaPeking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Yang, Jie
[1
,2
]
Xiang, Yang
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Peking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R ChinaPeking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Xiang, Yang
[1
]
Wu, Ming
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Peking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R ChinaPeking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Wu, Ming
[1
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Cao, Dongyan
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Peking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R ChinaPeking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Cao, Dongyan
[1
]
Wang, Jinhui
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Peking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R ChinaPeking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Wang, Jinhui
[1
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Yang, Jiaxin
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Peking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R ChinaPeking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
Yang, Jiaxin
[1
,2
]
机构:
[1] Peking Union Med Coll Hosp, Obstet & Gynecol, Beijing 100730, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R China
Objectives The aim of our study was to evaluate the feasibility of the modified International Germ Cell Cancer Collaborative Group risk classification system in Chinese female patients with malignant ovarian germ cell tumors and to identify predictive factors to enhance the risk classification system. Methods In this retrospective cohort analysis, patients with malignant ovarian germ cell tumors who received surgery with/without chemotherapy were included. These patients had been followed-up by Peking Union Medical College Hospital between 2011 to 2020. Patients without complete medical records or no follow-up information were excluded. Results The study enrolled a total of 271 patients. The risk model classified 106 (39.1%) patients as good-, 84 (31%) as intermediate-, and 81 (29.9%) as poor-risk. With a median follow-up time of 34 months (range 2-147), 48 (17.7%) recurrence and 16 (5.9%) deaths were observed. The risk classification significantly correlated with 3 year disease-free survival and overall survival (log rank p<0.001 and p=0.003, respectively). The survival outcomes of disease-free survival and overall survival were not statistically different among risk groups in patients who received neoadjuvant chemotherapy (log rank p=0.77 and 0.41, respectively). Univariate and multivariable analysis showed that tumor stage (p=0.033, hazard ratio (HR) 2.05, 95% confidence interval (CI) 1.06 to 3.96) was significantly associated with relapse or progression of disease. Patients over age 40 years exhibited a poor prognosis. Conclusion The modified International Germ Cell Cancer Collaborative Group risk classification system was efficacious in patients with malignant ovarian germ cell tumors and was significantly associated with disease-free survival and overall survival. Risk assessment after neoadjuvant chemotherapy may be more predictive than stratification at initial diagnosis. Age and tumor stage were definitive prognostic factors for germ cell tumors, which may need to be incorporated in the stratification system.
机构:
Chinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R China
Zhang, R.
Sun, Y. C.
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Chinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R China
Sun, Y. C.
Zhang, G. Y.
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Chinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R China
Zhang, G. Y.
Wu, L. Y.
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机构:
Chinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R China
Wu, L. Y.
Zuo, J.
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Chinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R ChinaChinese Acad Med Sci, Dept Gynecol Oncol, Canc Hosp, Peking Union Med Coll, Beijing 100021, Peoples R China
机构:
Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USAUniv Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Mahdi, Haider
Kumar, Sanjeev
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Mayo Clin, Dept Obstet & Gynecol, Div Gynecol Oncol, Rochester, MN USAUniv Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Kumar, Sanjeev
Seward, Shelly
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Wayne State Univ, Sch Med, Div Gynecol Oncol, Detroit, MI USAUniv Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Seward, Shelly
Semaan, Assaad
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Wayne State Univ, Sch Med, Div Gynecol Oncol, Detroit, MI USAUniv Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Semaan, Assaad
Batchu, Ramesh
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Wayne State Univ, Sch Med, Dept Surg, Barbara Ann Karmanos Canc Inst, Detroit, MI 48201 USAUniv Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Batchu, Ramesh
Lockhart, David
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Univ Washington, Dept Biostat, Seattle, WA 98195 USAUniv Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Lockhart, David
Tamimi, Hisham
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Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USAUniv Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
Tamimi, Hisham
Munkarah, Adnan R.
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Henry Ford Hlth Syst, Dept Womens Hlth Serv, Detroit, MI USAUniv Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA