Uncovering the Potential of CD40 Agonism to Enhance Immune Checkpoint Blockade

被引：2
|
作者：
Wu, Richard C. [1 ,2 ]
Luke, Jason J. [3 ,4 ]
机构：
[1] Ohio State Univ, James Comprehens Canc Ctr, Columbus, OH 43210 USA
[2] Div Med Oncol, Columbus, OH USA
[3] UPMC Hillman Canc Ctr, Pittsburgh, PA USA
[4] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA
来源：
CLINICAL CANCER RESEARCH | 2024年 / 30卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1158/1078-0432.CCR-23-2437
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this CCR Translations, we discuss the therapeutic potential of CD40 agonism, which stimulates antigen-presenting cells (APC) to activate effector T and NK cells. CD40 agonism may lead to development of an interferon-activated, T cell-inflamed tumor microenvironment and has the potential to facilitate long-term response with immune checkpoint blockade.
引用
收藏
页码：9 / 11
页数：3
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