In situ biocatalytic ATP regulated, transient supramolecular polymerization

被引:2
|
作者
Mishra, Ananya [1 ,2 ,3 ]
Das, Angshuman [1 ,2 ]
George, Subi J. [1 ,2 ]
机构
[1] Jawaharlal Nehru Ctr Adv Sci Res JNCASR, New Chem Unit, Supramol Chem Lab, Bangalore 560064, India
[2] Jawaharlal Nehru Ctr Adv Sci Res JNCASR, Sch Adv Mat SAMat, Bangalore 560064, India
[3] Univ Bristol, Sch Chem, Ctr Protolife Res, Ctr Organized Matter Chem, Bristol BS81TS, England
关键词
CHEMISTRY;
D O I
10.1039/d4tb01558d
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Temporal control over self-assembly processes is a highly desirable attribute that is efficiently exhibited by biological systems, such as actin filaments. In nature, various proteins undergo enzymatically catalysed chemical reactions that kinetically govern their structural and functional properties. Consequently, any stimuli that can alter their reaction kinetics can lead to a change in their growth or decay profiles. This underscores the urgent need to investigate bioinspired, adaptable and controllable synthetic materials. Herein we intend to develop a general strategy for controlling the growth and decay of self-assembled systems via enzymatically coupled reactions. We achieve this by the coupling of enzymes phosphokinase/phosphatase with a bolaamphiphilic cationic chromophore (<bold>PDI</bold>) which selectively self-assembles with ATP and disassembles upon its enzymatic hydrolysis. The aggregation process is efficiently regulated by the controlled in situ generation of ATP, through enzymatic reactions. By carefully managing the ATP generating components, we realize precise control over the self-assembly process. Moreover, we also show self-assembled structures with programmed temporal decay profiles through coupled enzymatic reactions of ATP generation and hydrolysis, essentially rendering the process dissipative. This work introduces a novel strategy to generate a reaction-coupled one-dimensional nanostructure with controlled dimensions inspired by biological systems.
引用
收藏
页码:9566 / 9574
页数:9
相关论文
共 50 条
  • [31] Supramolecular triacetylene polymerization
    不详
    CHEMICAL & ENGINEERING NEWS, 2000, 78 (25) : 38 - 38
  • [32] Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane
    Krieg, Elisha
    Albeck, Shira
    Weissman, Haim
    Shimoni, Eyal
    Rybtchinski, Boris
    PLOS ONE, 2013, 8 (05):
  • [33] Supramolecular liquid crystallinity as a mechanism of supramolecular polymerization
    Ciferri, A
    LIQUID CRYSTALS, 1999, 26 (04) : 489 - 494
  • [34] A dynamic supramolecular polymer with stimuli-responsive handedness for in situ probing of enzymatic ATP hydrolysis
    Kumar, Mohit
    Brocorens, Patrick
    Tonnele, Claire
    Beljonne, David
    Surin, Mathieu
    George, Subi J.
    NATURE COMMUNICATIONS, 2014, 5
  • [35] A dynamic supramolecular polymer with stimuli-responsive handedness for in situ probing of enzymatic ATP hydrolysis
    Mohit Kumar
    Patrick Brocorens
    Claire Tonnelé
    David Beljonne
    Mathieu Surin
    Subi J. George
    Nature Communications, 5
  • [36] Fabrication polymer nanofiber networks with regulated microstructures via RAFT polymerization of supramolecular gels in different solvents
    Guan, Wenxun
    Li, Shiqi
    Tang, Liming
    EUROPEAN POLYMER JOURNAL, 2019, 120
  • [37] Nanopore-regulated in situ polymerization for synthesis of homogeneous heparan sulfate with low dispersity
    Qiao, Meng
    Wang, Zhe
    Zhang, Junjie
    Li, Yanqi
    Chen, Liang-An
    Zhang, Fuming
    Dordick, Jonathan S.
    Linhardt, Robert J.
    Cai, Chao
    Huang, He
    Zhang, Xing
    CARBOHYDRATE POLYMERS, 2024, 341
  • [38] Biocatalytic Pathway Selection in Transient Tripeptide Nanostructures
    Pappas, Charalampos G.
    Sasselli, Ivan R.
    Ulijn, Rein V.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (28) : 8119 - 8123
  • [39] Performance improvement of magnesium oxychloride cement through in situ polymerization regulated by crosslinker structure
    Zhou, Wenguang
    Bai, Mingyang
    Li, Xingong
    Wu, Yiqiang
    Liu, Tao
    CONSTRUCTION AND BUILDING MATERIALS, 2025, 468
  • [40] Dissipative biocatalytic cascades and gated transient biocatalytic cascades driven by nucleic acid networks
    Ouyang, Yu
    Zhang, Pu
    Willner, Itamar
    SCIENCE ADVANCES, 2022, 8 (18)