Transition-Metal-Free Sulfoximidation of Sulfonylhydrazones for the Synthesis of N-Sulfanylidenehydrazonamides

被引：3

作者：

Huang, Tianming ^{[1
]}

Suleman, Muhammad ^{[2
]}

Xu, Zhengyu ^{[1
]}

Wei, Li ^{[1
]}

Yang, Yi ^{[3
]}

Zhang, Ming ^{[1
]}

Chen, Zhiyuan ^{[2
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China

[2] Hangzhou City Univ, Sch Med, Key Lab Novel Targets & Drug Study Neural Repair Z, Hangzhou 310015, Zhejiang, Peoples R China

[3] Zhejiang Univ, Coll Comp Sci & Technol, Hangzhou 310010, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 31期

基金：

中国国家自然科学基金;

关键词：

STEREOSELECTIVE-SYNTHESIS; FACILE SYNTHESIS; TOSYLHYDRAZONES; STRATEGIES; REAGENTS; AMINES;

D O I：

10.1021/acs.orglett.4c02170

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a transition-metal-free C-H bond sulfoximidation protocol of sulfonyl hydrazones with hypervalent iodine(III) reagents. A library of novel N-sulfaneylidenehydrazonamides was constructed via chemoselective C-N bond formation reactions at aldehyde C-H bonds of sulfonyl hydrazones in the presence of a base. The reaction demonstrated broad substrate group diversity under exceedingly mild reaction conditions, and excellent yields were achieved at room temperature.

引用

页码：6597 / 6601

页数：5

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