Insights into the Mechanism of Osteoporosis and the Available Treatment Options

被引:4
|
作者
Muniyasamy, Rajeshwari [1 ]
Manjubala, Inderchand [1 ]
机构
[1] Vellore Inst Technol, Sch Bio Sci & Technol, Vellore, Tamil Nadu, India
关键词
Primary and secondary osteoporosis; mechanism of osteoporosis; treatment options; anti-resorptive agents; anabolic therapy; bone mineral density; hormone replacement therapy; BONE-MINERAL DENSITY; INTRAVENOUS IBANDRONATE INJECTIONS; CLINICAL-PRACTICE GUIDELINES; POSTMENOPAUSAL WOMEN; STRONTIUM RANELATE; FRACTURE RISK; ZOLEDRONIC ACID; PREVENTION; TERIPARATIDE; ALENDRONATE;
D O I
10.2174/0113892010273783231027073117
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Osteoporosis, one of the most prevalent bone illnesses, majorly affects postmeno-pausal women and men over 50 years of age. Osteoporosis is associated with an increased susceptibility to fragility fractures and can result in persistent pain and significant impairment in affected individuals. The primary method for diagnosing osteoporosis involves the assessment of bone mineral density (BMD) through the utilisation of dual energy x-ray absorptiometry (DEXA). The integration of a fracture risk assessment algorithm with bone mineral density (BMD) has led to significant progress in the diagnosis of osteoporosis. Given that osteoporosis is a chronic condition and multiple factors play an important role in maintaining bone mass, comprehending its underlying mechanism is crucial for developing more effective pharma-ceutical interventions for the disease. The effective management of osteoporosis involves the utilisation of appropriate pharmacological agents in conjunction with suitable dietary interventions and lifestyle modifications. This review provides a comprehensive understanding of the types of osteoporosis and elucidates the currently available pharmacological treatment options and their related mechanism of action and usage.
引用
收藏
页码:1538 / 1551
页数:14
相关论文
共 50 条
  • [21] Current and future treatment options in osteoporosis
    Brewer, Linda
    Williams, David
    Moore, Alan
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 67 (04) : 321 - 331
  • [22] Current and future treatment options in osteoporosis
    Linda Brewer
    David Williams
    Alan Moore
    European Journal of Clinical Pharmacology, 2011, 67 : 321 - 331
  • [23] Osteoporosis and Fragility Fractures: currently available pharmacological options and future directions
    Dimai, Hans P.
    Fahrleitner-Pammer, Astrid
    BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2022, 36 (03):
  • [24] Is there a consensus among available treatment guidelines for osteoporosis?
    Greenwald, M
    Silverman, SL
    JOURNAL OF BONE AND MINERAL RESEARCH, 1996, 11 : T638 - T638
  • [25] The different types of osteoporosis and available treatment strategies
    Guillot, Xavier
    ACTUALITES PHARMACEUTIQUES, 2015, 54 (549): : 18 - 22
  • [26] Safety of treatment options available for postoperative pain
    Jin, Zhaosheng
    Lee, Christopher
    Zhang, Kalissa
    Gan, Tong J.
    Bergese, Sergio D.
    EXPERT OPINION ON DRUG SAFETY, 2021, 20 (05) : 549 - 559
  • [27] Currently available treatment options for anxiety disorders
    Baldwin, D.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2008, 11 : 73 - 73
  • [28] Controlling sialorrhoea: a review of available treatment options
    Potulska, A
    Friedman, A
    EXPERT OPINION ON PHARMACOTHERAPY, 2005, 6 (09) : 1551 - 1554
  • [29] Postmenopausal osteoporosis: risk evaluation and treatment options
    Bonaccorsi, Gloria
    Rizzati, Monica
    Salani, Lara
    Giganti, Melchiore
    MINERVA OBSTETRICS AND GYNECOLOGY, 2021, 73 (06) : 714 - 729
  • [30] Osteoporosis - Current pharmacologic options for prevention and treatment
    Isenbarger, DW
    Chapin, BL
    POSTGRADUATE MEDICINE, 1997, 101 (01) : 129 - +