IntroductionThis study focuses on investigating the relationship between serum neurofilament light chain (sNfL) and urinary albumin-to-creatinine ratio (uACR) among American adults aged 25-75.MethodsAn analysis was conducted on information gathered from 1741 individuals aged between 25 and 75 who participated in the National Health and Nutrition Examination Survey (NHANES) during the years 2013-2014. Generalized linear models were utilized, and restricted cubic spline (RCS) analysis was conducted to assess a non-linear relationship.ResultsUpon adjusting for multiple variables, a non-linear inverse J-shaped relationship was observed between sNfL and uACR. Compared with individuals in quartile 1 (Q1) of sNfL (2.8-8.3), those with quartile 4 (Q4) (>= 19.1) had an adjusted beta for uACR of 51.57.ConclusionsThe study found a J-shaped curve linking sNfL and uACR in American adults, with a turning point around log(sNfL) 2.928 pg/mL.
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Univ Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, GermanyUniv Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, Germany
Bunte, Kuebra
Wiessner, Christian
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Univ Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, GermanyUniv Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, Germany
Wiessner, Christian
Bahat, Guelistan
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Istanbul Univ, Istanbul Med Fac, Dept Internal Med, Div Geriatr, Istanbul, TurkiyeUniv Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, Germany
Bahat, Guelistan
Erdogan, Tugba
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Istanbul Univ, Istanbul Med Fac, Dept Internal Med, Div Geriatr, Istanbul, TurkiyeUniv Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, Germany
Erdogan, Tugba
Cruz-Jentoft, Alfonso J.
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Hosp Univ Ramon & Cajal IRYCIS, Serv Geriatria, Madrid, SpainUniv Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, Germany
Cruz-Jentoft, Alfonso J.
Zapf, Antonia
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Univ Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, GermanyUniv Med Ctr Hamburg Eppendorf, Ctr Expt Med Med Biometry & Epidemiol, Christoph-Probst-Weg 1,4th Floor, D-20246 Hamburg, Germany
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Shandong Second Med Univ, Affiliated Hosp, Ultrasound Dept, Weifang 261000, Shandong, Peoples R ChinaShandong Second Med Univ, Affiliated Hosp, Ultrasound Dept, Weifang 261000, Shandong, Peoples R China
Wang, Cuihua
Wang, Shuguang
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Weifang Peoples Hosp, Cardiac Crit Care & Rehabil Dept, Weifang 261000, Shandong, Peoples R ChinaShandong Second Med Univ, Affiliated Hosp, Ultrasound Dept, Weifang 261000, Shandong, Peoples R China
Wang, Shuguang
Wang, Ying
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Shandong Second Med Univ, Affiliated Hosp, Dept Med Records Room, Weifang 261053, Shandong, Peoples R ChinaShandong Second Med Univ, Affiliated Hosp, Ultrasound Dept, Weifang 261000, Shandong, Peoples R China
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New Taipei City Municipal Tucheng Hosp, Dept Nephrol, New Taipei, Taiwan
Chang Gung Univ, Coll Med, Taoyuan, TaiwanNew Taipei City Municipal Tucheng Hosp, Dept Nephrol, New Taipei, Taiwan
Hsiao, Ching Chung
Yang, An-Ming
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En Chu Kong Hosp, Dept Internal Med, 399 Fuxing Rd, New Taipei 237, Taiwan
Yuanpei Univ Med Technol, Dept Healthcare Management, Hsinchu 300, TaiwanNew Taipei City Municipal Tucheng Hosp, Dept Nephrol, New Taipei, Taiwan
Yang, An-Ming
Wang, Chikang
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Yuanpei Univ Med Technol, Dept Environm Engn & Hlth, Hsinchu 300, TaiwanNew Taipei City Municipal Tucheng Hosp, Dept Nephrol, New Taipei, Taiwan
Wang, Chikang
Lin, Chien-Yu
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En Chu Kong Hosp, Dept Internal Med, 399 Fuxing Rd, New Taipei 237, Taiwan
Yuanpei Univ Med Technol, Dept Environm Engn & Hlth, Hsinchu 300, Taiwan
Fu Jen Catholic Univ, Coll Med, Sch Med, New Taipei 242, TaiwanNew Taipei City Municipal Tucheng Hosp, Dept Nephrol, New Taipei, Taiwan
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US Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA
4770 Buford Highway,MS S-103-3, Atlanta, GA 30341 USAUS Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA
Seyler, Tiffany
Mazumder, Shrila
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US Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USAUS Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA
Mazumder, Shrila
Ahamed, Rayaj
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US Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USAUS Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA
Ahamed, Rayaj
Zhu, Wanzhe
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US Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USAUS Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA
Zhu, Wanzhe
Blount, Benjamin C.
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US Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USAUS Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA
Blount, Benjamin C.
Apelberg, Benjamin J.
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US FDA, Ctr Tobacco Prod, Silver Spring, MD USAUS Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA
Apelberg, Benjamin J.
Wang, Lanqing
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US Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USAUS Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Div Lab Sci, Natl Ctr Environm Hlth, Atlanta, GA USA
机构:
Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China
Huo, Xingwei
Jia, Shanshan
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Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China
Jia, Shanshan
Zhang, Xin
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Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China
Zhang, Xin
Sun, Lirong
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Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China
Tibet Univ Nationalities, Affiliated Hosp, Dept Internal Med 2, Xianyang, Shaanxi, Peoples R ChinaSichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China
Sun, Lirong
Liu, Xueting
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Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China
Liu, Xueting
Liu, Lu
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Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China
Liu, Lu
Zuo, Xianghao
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Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China
Zuo, Xianghao
Chen, Xiaoping
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Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R ChinaSichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China