First-in-human study of ABBV-400, a novel c-Met-targeting antibody-drug conjugate, in advanced solid tumors: Results in colorectal cancer

被引:0
|
作者
Sharma, Manish
Strickler, John H.
Sommerhalder, David
Kuboki, Yasutoshi
Perets, Ruth
Cohen, Jonathan
Raimbourg, Judith
Nakajima, Takako Eguchi
Yamamoto, Noboru
Cruz-Correa, Marcia
O'Neil, Bert
Ghiringhelli, Francois
Raghav, Kanwal Pratap Singh
Li, Rui
Thiele, Gladys Morrison
Aristide, Martha Raluca Neagu
Freise, Kevin Jay
de Almeida, Carla Biesdorf
Vasilopoulos, Athanasios
Powderly, John D., II
机构
[1] START Midwest, Grand Rapids, MI USA
[2] Duke Univ, Sch Med, Durham, NC USA
[3] NEXT Oncol, San Antonio, TX USA
[4] Natl Canc Ctr Hosp East, Kashiwa, Chiba, Japan
[5] Rambam Med Ctr, Haifa, Israel
[6] Technion Israel Inst Technol, Haifa, Israel
[7] Hebrew Univ Jerusalem, Sharett Inst Oncol, Wohl Inst Translat Med, Hadassah Med Ctr,Hadassh Hebrew Univ Med Ctr, Jerusalem, Israel
[8] Ctr Rene Gauducheau, Insit Cancerol Ouest, St Herblain, France
[9] Kyoto Univ, Grad Sch Med, Kyoto, Japan
[10] Natl Canc Ctr, Tokyo, Japan
[11] Univ Puerto Rico, Med Sci Campus, San Juan, PR USA
[12] Pan Amer Ctr Oncol Trials, San Juan, PR USA
[13] Community Hlth Canc Ctr North, Indianapolis, IN USA
[14] Ctr Georges Francois Leclerc, Dijon, France
[15] Univ Texas MD Anderson Canc Ctr, Houston, TX USA
[16] AbbVie Inc, N Chicago, IL USA
[17] Carolina Biooncol Inst, Huntersville, NC USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3515
引用
收藏
页数:1
相关论文
共 50 条
  • [41] First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors
    Hassan, Raffit
    Blumenschein, George R., Jr.
    Moore, Kathleen N.
    Santin, Alessandro D.
    Kindler, Hedy L.
    Nemunaitis, John J.
    Seward, Shelly M.
    Thomas, Anish
    Kim, Stella K.
    Rajagopalan, Prabhu
    Walter, Annette O.
    Laurent, Dirk
    Childs, Barrett H.
    Sarapa, Nenad
    Elbi, Cem
    Bendell, Johanna C.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (16) : 1824 - +
  • [42] Phase I study of ABBV-706, an anti-SEZ6 antibody-drug conjugate, alone or in combination in adults with advanced solid tumors
    Chandana, S.
    Garmezy, B.
    Dowlati, A.
    Sharma, M. R.
    Henner, W.
    Robinson, R.
    Hingorani, P.
    Jeng, E.
    Papadopoulos, K. P.
    ANNALS OF ONCOLOGY, 2023, 34 : S1077 - S1077
  • [43] First-in-Human Phase I Study of ABBV-838, an Antibody-Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma
    Vij, Ravi
    Nath, Rajneesh
    Afar, Daniel E. H.
    Mateos, Maria Victoria
    Berdeja, Jesus G.
    Raab, Marc S.
    Guenther, Andreas
    Martinez-Lopez, Joaquin
    Jakubowiak, Andrzej J.
    Leleu, Xavier
    Weisel, Katja
    Wong, Shekman
    Gulbranson, Scott
    Sheridan, James P.
    Reddy, Anita
    Paiva, Bruno
    Singhal, Anil
    San-Miguel, Jesus F.
    Moreau, Philippe
    CLINICAL CANCER RESEARCH, 2020, 26 (10) : 2308 - 2317
  • [44] Preliminary results from a phase 1 study of the antibody-drug conjugate ABBV-221 in patients with solid tumors likely to express EGFR.
    Calvo, Emiliano
    Cleary, James M.
    Moreno, Victor
    Gifford, Maryella
    Roberts-Rapp, Lisa
    Ansel, Peter J.
    Mittapalli, Rajendar K.
    Lee, Ho-jin
    Hu, Beibei
    Barch, David
    Ocampo, Christopher Joseph
    Tolcher, Anthony W.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [45] BYON3521, a novel effective and safe c-Met targeting antibody-drug conjugate.
    Groothuis, Patrick
    Jacobs, Danielle
    Hermens, Inge
    Damming, Desiree
    Mattaar, Ellen
    Rouwette, Myrthe
    van der Vleuten, Monique
    Sesink, Aloys
    Dijcks, Fred
    Coumans, Ruud
    Blomenrohr, Marion
    Ubink, Ruud
    van der Lee, Miranda
    Dokter, Wim H. A.
    CANCER RESEARCH, 2021, 81 (13)
  • [46] Phase Ia, first-in-human study of AbGn-107, a novel antibody-drug conjugate (ADC), in patients with gastric, colorectal, pancreatic, or biliary cancers
    Ko, Andrew H.
    Coveler, Andrew L.
    Schlechter, Benjamin L.
    Bekaii-Saab, Tanios S.
    Wolpin, Brian M.
    Clark, Jeffrey William
    Cheng, Yi-Lin
    Cheng, Ting-Ying
    Langecker, Peter J.
    Lin, Shih-Yao
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (04)
  • [47] Initial results from a first-in-human study of the B7-H4-directed antibody-drug conjugate (ADC) AZD8205 (puxitatug samrotecan) in patients with advanced/metastatic solid tumors
    Meric-Bernstam, F.
    Naito, Y.
    Gaillard, S.
    Shimoi, T.
    Chung, V.
    Davis, A. A.
    Proia, T.
    Ayyoub, A.
    Kulkarni, M.
    Upadhyay, S.
    Miller, N.
    Luheshi, N.
    Varga, A.
    Oh, D-Y.
    Mileshkin, L.
    ANNALS OF ONCOLOGY, 2024, 35 : S485 - S486
  • [48] A phase I, first-in-human study of argx-111, a monoclonal antibody targeting c-met in patients with solid tumors.
    Aftimos, Philippe G.
    Barthelemy, Philippe
    Rolfo, Christian D.
    Hanssens, Valerie
    De Jonge, Natalie
    Silence, Karen
    Dreier, Torsten
    de Haard, Hans
    Peeters, Marc
    Thibault, Alain
    Awada, Ahmad
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [49] A phase I, first-in-human study of TAK-164, an antibody-drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C
    Kim, Richard
    Leal, Alexis D.
    Parikh, Aparna
    Ryan, David P.
    Wang, Shining
    Bahamon, Brittany
    Gupta, Neeraj
    Moss, Aaron
    Pye, Joanna
    Miao, Harry
    Inguilizian, Haig
    Cleary, James M.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023, 91 (04) : 291 - 300
  • [50] CKD-703, a novel antibody-drug conjugate targeting cMET with an enhanced therapeutic index in solid tumors
    Lee, Kwanwoo
    Kim, Sue-Youn
    Hong, Hye-Jin
    Park, Eunjeong
    Park, Jungok
    Hong, Seong-Ho
    Bae, Daekwon
    Ha, Nina
    Yeon, Sohn-Ji
    Hwang, Inchang
    Kim, Semi
    Lee, Yoonseok
    Lee, Ju-Hee
    CANCER RESEARCH, 2024, 84 (07)