Diffusion MRI in prostate cancer with ultra-strong whole-body gradients

被引:0
|
作者
Molendowska, Malwina [1 ]
Palombo, Marco [1 ,2 ]
Foley, Kieran G. [3 ]
Narahari, Krishna [4 ]
Fasano, Fabrizio [5 ,6 ]
Jones, Derek K. [1 ]
Alexander, Daniel C. [7 ]
Panagiotaki, Eleftheria [7 ]
Tax, Chantal M. W. [1 ,8 ]
机构
[1] Cardiff Univ, Cardiff Univ Brain Res Imaging Ctr CUBR, Cardiff, Wales
[2] Cardiff Univ, Sch Comp Sci & Informat, Cardiff, Wales
[3] Cardiff Univ, Sch Med, Div Canc & Genet, Cardiff, Wales
[4] Cardiff & Vale Univ Hlth Board, Heath Pk Campus, Cardiff, Wales
[5] Siemens Healthcare Ltd, Camberley, England
[6] Siemens Healthcare GmbH, Erlangen, Germany
[7] UCL, Ctr Med Image Comp, London, England
[8] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands
基金
英国工程与自然科学研究理事会; 英国科研创新办公室; 英国惠康基金;
关键词
diagnostic imaging; diffusion MRI; high b-values; prostate cancer; strong gradients; TISSUE; DISTORTIONS; RELAXATION; PARAMETERS;
D O I
10.1002/nbm.5229
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Diffusion-weighted MRI (dMRI) is universally recommended for the detection and classification of prostate cancer (PCa), with PI-RADS recommendations to acquire b-values of >= 1.4 ms/mu m(2). However, clinical dMRI suffers from a low signal-to-noise ratio (SNR) as the consequence of prolonged echo times (TEs) attributable to the limited gradient power in the range of 40-80 mT/m. To overcome this, MRI systems with strong gradients have been designed but so far have mainly been applied in the brain. The aim of this work was to assess the feasibility, data quality, SNR and contrast-to-noise ratio (CNR) of measurements in PCa with a 300 mT/m whole-body system. A cohort of men without and with diagnosed PCa were imaged on a research-only 3T Connectom Siemens MRI system equipped with a gradient amplitude of 300 mT/m. dMRI at high b-values were acquired using high gradient amplitudes and compared with gradient capabilities mimicking clinical systems. Data artefacts typically amplified with stronger gradients were assessed and their correction evaluated. The SNR gains and lesion-to-healthy tissue CNR were statistically tested investigating the effect of protocol and b-value. The diagnostic quality of the images for different dMRI protocols was assessed by an experienced radiologist using a 5-point Likert scale and an adapted PI-QUAL scoring system. The strong gradients for prostate dMRI allowed a significant gain in SNR per unit time compared with clinical gradients. Furthermore, a 1.6-2.1-fold increase in CNR was observed. Despite the more pronounced artefacts typically associated with strong gradients, a satisfactory correction could be achieved. Smoother and less biased parameter maps were obtained with protocols at shorter TEs. The results of this study show that dMRI in PCa with a whole-body 300-mT/m scanner is feasible without a report of physiological effects, SNR and CNR can be improved compared with lower gradient strengths, and artefacts do not negate the benefits of strong gradients and can be ameliorated. This assessment provides the first essential step towards unveiling the full potential of cutting-edge scanners, now increasingly becoming available, to advance early detection and diagnostic precision.
引用
收藏
页数:15
相关论文
共 50 条
  • [31] Advancing Prostate Cancer Staging: A Single-Step Approach With Bi-parametric and Whole-Body Diffusion MRI in an African Cohort
    Frimpong, George Asafu Adjaye
    Aboagye, Evans
    Asante, Emmanuel
    Appiah, Kwaku Addai A.
    Owusu-Afriyie, Osei
    Asare, Adwoa O.
    Atuobi, Dorcas
    Akpaloo, Bernard D.
    Antwi, Bright
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (05)
  • [32] Registration Strategies for Whole-Body Diffusion-Weighted MRI Stitching
    Ceranka, Jakub
    Polfliet, Mathias
    Lecouvet, Frederic
    Michoux, Nicolas
    de Mey, Johan
    Vandemeulebroucke, Jef
    COMPUTATIONAL DIFFUSION MRI, 2016, : 195 - 206
  • [33] Whole-body magnetic resonance imaging (WB-MRI) with diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in prostate cancer: Prevalence and clinical significance o incidental findings
    Kumasaka, Soma
    Motegi, Shunichi
    Kumasaka, Yuka
    Nishikata, Tatsuya
    Otomo, Masami
    Tsushima, Yoshito
    BRITISH JOURNAL OF RADIOLOGY, 2022, 95 (1131):
  • [34] Whole-body MRI versus whole-body MDCT for staging of multiple myeloma
    Baur-Melnyk, Andrea
    Buhmann, Sonja
    Becker, Christoph
    Schoenberg, Stefan Oswald
    Lang, Nicola
    Bartl, Reiner
    Reiser, Maximilian Ferdinand
    AMERICAN JOURNAL OF ROENTGENOLOGY, 2008, 190 (04) : 1097 - 1104
  • [35] Simultaneous whole-body PET/MRI with integrated multiparametric MRI for primary staging of high-risk prostate cancer
    Sascha Kaufmann
    Stephan Kruck
    Sergios Gatidis
    Tobias Hepp
    Wolfgang M. Thaiss
    Jörg Hennenlotter
    Johannes Schwenck
    Marcus Scharpf
    Konstantin Nikolaou
    Arnulf Stenzl
    Gerald Reischl
    Christian la Fougère
    Jens Bedke
    World Journal of Urology, 2020, 38 : 2513 - 2521
  • [36] Simultaneous whole-body PET/MRI with integrated multiparametric MRI for primary staging of high-risk prostate cancer
    Kaufmann, Sascha
    Kruck, Stephan
    Gatidis, Sergios
    Hepp, Tobias
    Thaiss, Wolfgang M.
    Hennenlotter, Joerg
    Schwenck, Johannes
    Scharpf, Marcus
    Nikolaou, Konstantin
    Stenzl, Arnulf
    Reischl, Gerald
    la Fougere, Christian
    Bedke, Jens
    WORLD JOURNAL OF UROLOGY, 2020, 38 (10) : 2513 - 2521
  • [37] WHOLE-BODY MRI FOR ANALYSIS OF BODY COMPOSITION
    Kullberg, Joel
    2010 7TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO, 2010, : 1065 - 1066
  • [38] Application of whole-body MRI to detect the recurrence of lung cancer
    Lee, Min Hee
    Kim, So Ri
    Park, Seung Yong
    Park, Seoung Ju
    Lee, Eun Jung
    Ji, Gong Yong
    Lee, Yong Chul
    MAGNETIC RESONANCE IMAGING, 2012, 30 (10) : 1439 - 1445
  • [39] Pediatric Cancer Predisposition Imaging: Focus on Whole-Body MRI
    Greer, Mary-Louise C.
    Voss, Stephan D.
    States, Lisa J.
    CLINICAL CANCER RESEARCH, 2017, 23 (11) : E6 - E13
  • [40] Psychological characteristics and satisfaction for the whole-body MRI in cancer screening
    Busacchio, Derna
    Mazzoni, Davide
    Mazzocco, Ketti
    Pricolo, Paola
    Summers, Paul E.
    Petralia, Giuseppe
    Pravettoni, Gabriella
    PSYCHOLOGY HEALTH & MEDICINE, 2023, 28 (02) : 548 - 554