Base-Promoted Nucleophilic Phosphorylation of Benzyl Fluorides via C(sp3)-F Cleavage

被引：2
|
作者：
Sun, Bing-Qian [1 ,2 ]
Yang, Jia [1 ,2 ]
Fan, Lei [1 ,2 ]
Xu, Qian [3 ]
Wang, Shuai [1 ,2 ]
Zhong, Hong [1 ,2 ]
Xiang, Hao-Yue [1 ]
机构：
[1] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China
[2] Cent South Univ, Hunan Prov Key Lab Efficient & Clean Utilizat Mang, Changsha 410083, Peoples R China
[3] Hunan Res Inst Chem Ind, Changsha 410014, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 16期
关键词：
F BOND ACTIVATION; CATALYZED ALPHA-ARYLATION; PHOSPHORUS; SUBSTITUTION; DERIVATIVES; EFFICIENT; HALIDES; ROUTE;
D O I：
10.1021/acs.joc.4c00098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, a transition-metal-free phosphorylation of benzyl fluorides with P(O)-H compounds is disclosed. In the presence of t BuOK, various benzyl fluorides react with P(O)-H compounds to produce the corresponding benzyl phosphine oxides, phosphinates, and phosphonates in good to high yields. This base-promoted phosphorylation reaction offers a facile and general strategy for the construction of a C(sp(3))-P bond.
引用
收藏
页码：11739 / 11746
页数：8
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