Cardiac magnetic resonance imaging in the evaluation and management of mitral valve prolapse - a comprehensive review

Mitral valve prolapse is a common valve disorder that usually has a benign prognosis unless there is significant regurgitation or LV impairment. However, a subset of patients are at an increased risk of ventricular arrhythmias and sudden cardiac death, which has led to the recognition of "arrhythmic mitral valve prolapse" as a clinical entity. Emerging risk factors include mitral annular disjunction and myocardial fibrosis. While echocardiography remains the primary method of evaluation, cardiac magnetic resonance has become crucial in managing this condition. Cine magnetic resonance sequences provide accurate characterization of prolapse and annular disjunction, assessment of ventricular volumes and function, identification of early dysfunction and remodeling, and quantitative assessment of mitral regurgitation when integrated with flow imaging. However, the unique strength of magnetic resonance lies in its ability to identify tissue changes. T1 mapping sequences identify diffuse fibrosis, in turn related to early ventricular dysfunction and remodeling. Late gadolinium enhancement sequences detect replacement fibrosis, an independent risk factor for ventricular arrhythmias and sudden cardiac death. There are consensus documents and reviews on the use of cardiac magnetic resonance specifically in arrhythmic mitral valve prolapse. However, in this article, we propose an algorithm for the broader use of cardiac magnetic resonance in managing this condition in various scenarios. Future advancements may involve implementing techniques for tissue characterization and flow analysis, such as 4D flow imaging, to identify patients with ventricular dysfunction and remodeling, increased arrhythmic risk, and more accurate grading of mitral regurgitation, ultimately benefiting patient selection for surgical therapy. Mitral valve prolapse is typically first diagnosed by echocardiography; guidelines indicate cardiac magnetic resonance as a secondary tool when echocardiography is insufficient. However, in mitral valve prolapse, in clinical practice, cardiac magnetic resonance is often used more extensively to clarify issues such as syncope, disproportionate remodeling, and arrhythmias. In fact, cardiac magnetic resonance offers a range of tools, including morpho-functional and volumetric studies, flow studies, and tissue characterization, which provide crucial information for patient prognostic stratification, helping to assess arrhythmic risk and valvular function and remodeling, as well as informing surgical planning. image