Bridging the gap: a translational perspective in spinal cord injury
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作者:
Hassan, Omar Imad
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Univ Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
Univ Toronto, Inst Med Sci, Toronto, ON, CanadaUniv Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
Hassan, Omar Imad
[1
,2
]
Takamiya, Soichiro
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Univ Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, CanadaUniv Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
Takamiya, Soichiro
[1
]
Asgarihafshejani, Azam
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Univ Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, CanadaUniv Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
Asgarihafshejani, Azam
[1
]
Fehlings, Michael G.
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Univ Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
Univ Toronto, Inst Med Sci, Toronto, ON, Canada
Univ Hlth Network, Toronto Western Hosp, Krembil Neurosci Ctr, Div Neurosurg, Toronto, ON, Canada
Univ Toronto, Dept Surg, Div Neurosurg & Spine Program, Toronto, ON, CanadaUniv Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
Fehlings, Michael G.
[1
,2
,3
,4
]
机构:
[1] Univ Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[3] Univ Hlth Network, Toronto Western Hosp, Krembil Neurosci Ctr, Div Neurosurg, Toronto, ON, Canada
[4] Univ Toronto, Dept Surg, Div Neurosurg & Spine Program, Toronto, ON, Canada
Traumatic spinal cord injury (SCI) is a devastating and complex condition to treat with no curative options. In the past few decades, rapid advancements in our understanding of SCI pathophysiology as well as the mergence of new treatments has created more optimism. Focusing on clinical translation, this paper provides a comprehensive overview of SCI through its epidemiology, pathophysiology, currently employed management strategies, and emerging therapeutic approaches. Additionally, it emphasizes the importance of addressing the heavy quality of life (QoL) challenges faced by SCI patients and their desires, providing a basis to tailor patient-centric forms of care. Furthermore, this paper discusses the frequently encountered barriers in translation from preclinical models to clinical settings. It also seeks to summarize significant completed and ongoing SCI clinical trials focused on neuroprotective and neuroregenerative strategies. While developing a cohesive regenerative treatment strategy remains challenging, even modest improvements in sensory and motor function can offer meaningful benefits and motivation for patients coping with this highly debilitating condition.
机构:
Univ Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USAUniv Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USA
Schomberg, Dominic T.
Miranpuri, Gurwattan S.
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Univ Wisconsin, Dept Neurol Surg, Sch Med & Publ Hlth, Madison, WI USAUniv Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USA
Miranpuri, Gurwattan S.
Chopra, Abhishek
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Univ Wisconsin, Dept Neurol Surg, Sch Med & Publ Hlth, Madison, WI USAUniv Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USA
Chopra, Abhishek
Patel, Kush
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Univ Wisconsin, Dept Neurol Surg, Sch Med & Publ Hlth, Madison, WI USAUniv Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USA
Patel, Kush
Meudt, Jennifer J.
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Univ Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USAUniv Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USA
Meudt, Jennifer J.
Tellez, Armando
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Alizee Pathol LLC, Thurmont, MD USAUniv Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USA
Tellez, Armando
Resnick, Daniel K.
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Univ Wisconsin, Dept Neurol Surg, Sch Med & Publ Hlth, Madison, WI USAUniv Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USA
Resnick, Daniel K.
Shanmuganayagam, Dhanansayan
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Univ Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USAUniv Wisconsin Madison, Biomed & Genom Res Grp, Dept Anim Sci, Madison, WI USA
机构:
Translational Neuroscience Facility, School of Medical Sciences, the University of New South Wales (UNSW Australia)
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College LondonTranslational Neuroscience Facility, School of Medical Sciences, the University of New South Wales (UNSW Australia)
Andrew P Tosolini
Renée Morris
论文数: 0引用数: 0
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Translational Neuroscience Facility, School of Medical Sciences, the University of New South Wales (UNSW Australia)Translational Neuroscience Facility, School of Medical Sciences, the University of New South Wales (UNSW Australia)
机构:
Univ New S Wales, Sch Med Sci, Translat Neurosci Facil, Sydney, NSW, Australia
UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, EnglandUniv New S Wales, Sch Med Sci, Translat Neurosci Facil, Sydney, NSW, Australia
Tosolini, Andrew P.
Morris, Renee
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Univ New S Wales, Sch Med Sci, Translat Neurosci Facil, Sydney, NSW, AustraliaUniv New S Wales, Sch Med Sci, Translat Neurosci Facil, Sydney, NSW, Australia
机构:
Univ New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, AustraliaUniv New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
Tonkin, Ryan S.
Mao, Yilin
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机构:
Univ Technol Sydney, Fac Sci, Sch Med & Mol Biosci, Sydney, NSW 2007, AustraliaUniv New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
Mao, Yilin
O'Carroll, Simon J.
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Univ Auckland, Fac Med & Hlth Sci, Dept Anat Radiol, Auckland 1, New Zealand
Univ Auckland, Fac Med & Hlth Sci, Ctr Brain Res, Auckland 1, New ZealandUniv New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
O'Carroll, Simon J.
Nicholson, Louise F. B.
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Univ Auckland, Fac Med & Hlth Sci, Dept Anat Radiol, Auckland 1, New Zealand
Univ Auckland, Fac Med & Hlth Sci, Ctr Brain Res, Auckland 1, New ZealandUniv New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
Nicholson, Louise F. B.
Green, Colin R.
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机构:
Univ Auckland, Fac Med & Hlth Sci, Dept Ophthalmol, Auckland 1, New ZealandUniv New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
Green, Colin R.
Gorrie, Catherine A.
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机构:
Univ Technol Sydney, Fac Sci, Sch Med & Mol Biosci, Sydney, NSW 2007, AustraliaUniv New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
Gorrie, Catherine A.
Moalem-Taylor, Gila
论文数: 0引用数: 0
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Univ New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, AustraliaUniv New S Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia