Bridging the gap: a translational perspective in spinal cord injury

被引:0
|
作者
Hassan, Omar Imad [1 ,2 ]
Takamiya, Soichiro [1 ]
Asgarihafshejani, Azam [1 ]
Fehlings, Michael G. [1 ,2 ,3 ,4 ]
机构
[1] Univ Hlth Network, Krembil Brain Inst, Div Genet & Dev, Toronto, ON, Canada
[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[3] Univ Hlth Network, Toronto Western Hosp, Krembil Neurosci Ctr, Div Neurosurg, Toronto, ON, Canada
[4] Univ Toronto, Dept Surg, Div Neurosurg & Spine Program, Toronto, ON, Canada
关键词
spinal cord injury; neuroregeneration; animal models; clinical trials; pathophysiology; TRANSCRANIAL MAGNETIC STIMULATION; PLURIPOTENT STEM-CELLS; PROMOTES FUNCTIONAL RECOVERY; CLINICAL-PRACTICE GUIDELINE; MOTOR CORTEX; CHRONIC PAIN; BLOOD-FLOW; ICCP PANEL; DECOMPRESSIVE SURGERY; AXONAL REGENERATION;
D O I
10.3389/ebm.2024.10266
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Traumatic spinal cord injury (SCI) is a devastating and complex condition to treat with no curative options. In the past few decades, rapid advancements in our understanding of SCI pathophysiology as well as the mergence of new treatments has created more optimism. Focusing on clinical translation, this paper provides a comprehensive overview of SCI through its epidemiology, pathophysiology, currently employed management strategies, and emerging therapeutic approaches. Additionally, it emphasizes the importance of addressing the heavy quality of life (QoL) challenges faced by SCI patients and their desires, providing a basis to tailor patient-centric forms of care. Furthermore, this paper discusses the frequently encountered barriers in translation from preclinical models to clinical settings. It also seeks to summarize significant completed and ongoing SCI clinical trials focused on neuroprotective and neuroregenerative strategies. While developing a cohesive regenerative treatment strategy remains challenging, even modest improvements in sensory and motor function can offer meaningful benefits and motivation for patients coping with this highly debilitating condition.
引用
收藏
页数:25
相关论文
共 50 条
  • [1] Nanomedicine innovations in spinal cord injury management: Bridging the gap
    Rahmanian, Mohsen
    Ghahremani, Amirali
    Kesharwani, Prashant
    Oroojalian, Fatemeh
    Sahebkar, Amirhossein
    ENVIRONMENTAL RESEARCH, 2023, 235
  • [2] Olfactory ensheathing cells: Bridging the gap in spinal cord injury
    Bartolomei, JC
    Greer, CA
    NEUROSURGERY, 2000, 47 (05) : 1057 - 1069
  • [3] Introduction: Spinal cord injury: Bridging the gap and prospects for recovery
    Hulsebosch, CE
    Sherwood, AM
    Waldrep, K
    JOURNAL OF NEUROTRAUMA, 1997, 14 (08) : 477 - 478
  • [4] Model for bridging the translational "valleys of death" in spinal cord injury research
    Barrable, Bill
    Thorogood, Nancy
    Noonan, Vanessa
    Tomkinson, Jocelyn
    Joshi, Phalgun
    Stephenson, Ken
    Barclay, John
    Burns, Katharina Kovacs
    JOURNAL OF HEALTHCARE LEADERSHIP, 2014, 6 : 15 - 27
  • [5] Bridging the gap: Transitional rehabilitation services for people with spinal cord injury
    Kendall, MB
    Ungerer, G
    Dorsett, P
    DISABILITY AND REHABILITATION, 2003, 25 (17): : 1008 - 1015
  • [6] Olfactory ensheathing cells: Bridging the gap in spinal cord injury - Comment
    Tator, CH
    NEUROSURGERY, 2000, 47 (05) : 1069 - 1069
  • [7] Bridging the gap: From discovery to clinical trials in spinal cord injury
    Hulsebosch, CE
    Hains, BC
    Waldrep, K
    Young, W
    JOURNAL OF NEUROTRAUMA, 2000, 17 (12) : 1117 - 1128
  • [8] Bridging the gap in spinal cord regeneration
    Schwab, ME
    NATURE MEDICINE, 1996, 2 (09) : 976 - 977
  • [9] Bridging areas of injury in the spinal cord
    Bunge, MB
    NEUROSCIENTIST, 2001, 7 (04): : 325 - 339
  • [10] Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury
    Ahuja, Christopher S.
    Fehlings, Michael
    STEM CELLS TRANSLATIONAL MEDICINE, 2016, 5 (07) : 914 - 924