Palladium-Catalyzed Cascade Cyclization and Alkynylation of 2-Alkynylphenols with Bromoalkynes

被引：0

作者：

Feng, Yu ^{[1
]}

Zhang, Jiangjie ^{[2
]}

Ying, Jun ^{[2
]}

Lv, Yue ^{[1
]}

Tang, Keqi ^{[1
]}

Luo, Junfei ^{[1
]}

机构：

[1] Ningbo Univ, Inst Mass Spectrometry, Sch Mat Sci & Chem Engn, Ningbo 315211, Peoples R China

[2] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Hangzhou 310018, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 09期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Palladium; Benzofurans; Cyclization; Alkynylation; 2-Alkynylphenols;

D O I：

10.1002/ajoc.202400283

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed cascade cyclization and alkynylation of 2-alkynylphenols with bromoalkynes to the synthesis of 3-alkynylbenzofuran scaffolds has been developed. A variety of 3-alkynylbenzofuran derivatives were prepared in good yields under mild conditions. Notably, this protocol was applied to the late-stage modification of bioactive molecule. A palladium-catalyzed cascade cyclization and alkynylation of 2-alkynylphenols with bromoalkynes has been reported. The method provides an efficient tool to construct the 3-alkynylbenzofuran derivatives, as well as late-stage modifies the bioactive molecule. image

引用

页数：4

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