Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer

被引：0
|
作者：
Li, Shuhui [1 ]
Liu, Yuansheng [2 ]
Sui, Xiaojun [3 ,4 ]
Zhuo, Yuzhen [3 ]
Siqi, He [4 ]
Sijia, Zhang [4 ]
Hui, Zhang [3 ]
Dihua, Li [3 ]
Dapeng, Zhang [3 ]
Lei, Yang [3 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China
[2] Tianjin Union Med Ctr, Dept Colorectal Surg, Tianjin 300000, Peoples R China
[3] Tianjin Med Univ, Tianjin Nankai Hosp, Tianjin Key Lab Organ Injury & ITCWM Repair Associ, Tianjin 300100, Peoples R China
[4] Tianjin Med Univ, Grad Sch, Tianjin 300270, Peoples R China
来源：
NANOMEDICINE | 2024年 / 19卷 / 24期
关键词：
F18-FDG micro-PET/CT imaging; gemcitabine; liposomes; pancreatic cancer; tubular alfalfa glycosides I; tumor microenvironment; CHOLESTEROL; PACLITAXEL; SAPONINS; KINETICS; RELEASE;
D O I：
10.1080/17435889.2024.2382076
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To evaluate the anti-pancreatic cancer effect of novel Tubeimoside I multifunctional liposomes combined with gemcitabine. Methods: Liposomes were prepared through the thin film hydration method, with evaluations conducted on parameters including encapsulation efficiency (EE%), particle size, polydispersity index (PDI), zeta potential (ZP), storage stability, and release over a 7-day period. The cellular uptake rate, therapeutic efficacy in vitro and in vivo and the role of immune microenvironment modulation were evaluated. Results: The novel Tubeimoside I multifunctional liposomal exhibited good stability, significant anti-cancer activity, and immune microenvironment remodeling effects. Furthermore, it showed a safety profile. Conclusion: This study underscores the potential of Novel Tubeimoside I multifunctional liposomal as a promising treatment option for pancreatic cancer.
引用
收藏
页码：1977 / 1993
页数：17
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