Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer

被引：0

作者：

Li, Shuhui ^{[1
]}

Liu, Yuansheng ^{[2
]}

Sui, Xiaojun ^{[3
,4
]}

Zhuo, Yuzhen ^{[3
]}

Siqi, He ^{[4
]}

Sijia, Zhang ^{[4
]}

Hui, Zhang ^{[3
]}

Dihua, Li ^{[3
]}

Dapeng, Zhang ^{[3
]}

Lei, Yang ^{[3
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China

[2] Tianjin Union Med Ctr, Dept Colorectal Surg, Tianjin 300000, Peoples R China

[3] Tianjin Med Univ, Tianjin Nankai Hosp, Tianjin Key Lab Organ Injury & ITCWM Repair Associ, Tianjin 300100, Peoples R China

[4] Tianjin Med Univ, Grad Sch, Tianjin 300270, Peoples R China

来源：

NANOMEDICINE | 2024年 / 19卷 / 24期

关键词：

F18-FDG micro-PET/CT imaging; gemcitabine; liposomes; pancreatic cancer; tubular alfalfa glycosides I; tumor microenvironment; CHOLESTEROL; PACLITAXEL; SAPONINS; KINETICS; RELEASE;

D O I：

10.1080/17435889.2024.2382076

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To evaluate the anti-pancreatic cancer effect of novel Tubeimoside I multifunctional liposomes combined with gemcitabine. Methods: Liposomes were prepared through the thin film hydration method, with evaluations conducted on parameters including encapsulation efficiency (EE%), particle size, polydispersity index (PDI), zeta potential (ZP), storage stability, and release over a 7-day period. The cellular uptake rate, therapeutic efficacy in vitro and in vivo and the role of immune microenvironment modulation were evaluated. Results: The novel Tubeimoside I multifunctional liposomal exhibited good stability, significant anti-cancer activity, and immune microenvironment remodeling effects. Furthermore, it showed a safety profile. Conclusion: This study underscores the potential of Novel Tubeimoside I multifunctional liposomal as a promising treatment option for pancreatic cancer.

引用

页码：1977 / 1993

页数：17

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