The generation of human induced pluripotent stem cell lines from individuals of Black African ancestry in South Africa

被引：0
|
作者：
Naidoo, Jerolen [1 ,2 ]
Hurrell, Tracey [1 ]
Scholefield, Janine [1 ,2 ,3 ]
机构：
[1] CSIR, Bioengn & Integrated Genom Grp, Future Prod Chem Cluster, POB 395, ZA-0001 Pretoria, South Africa
[2] Univ Cape Town, Fac Hlth Sci, Dept Human Biol, Private Bag X3, ZA-7701 Rondebosch, South Africa
[3] Univ Witwatersrand, Fac Hlth Sci, Div Human Genet, POB 1038, ZA-2000 Johannesburg, South Africa
来源：
STEM CELL RESEARCH | 2024年 / 81卷
基金：
新加坡国家研究基金会;
关键词：
hiPSC; African ancestry; African representation; Hepatocyte-like cells; Cortical neurons; GENOMES;
D O I：
10.1016/j.scr.2024.103534
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The lack of equitable representation of African diversity in scientific resources, such as genome-wide association studies and human induced pluripotent stem cell (hiPSC) repositories, has perpetuated inequalities in the advancement of health research. HiPSCs could be transformative in regenerative and precision medicine, therefore, the generation of diverse lines is critical in the establishment of African-relevant preclinical cellular models. HiPSC lines were derived from two healthy donors of Black African ancestry using Sendai virus reprogramming of dermal fibroblasts, and characterised to confirm stemness markers, trilineage differentiation, and genetic integrity. These hiPSCs represent a valuable resource for modelling African relevant disease biology.
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页数：6
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