Electrochemical detection of the cardiac biomarker cardiac troponin I
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作者:
Qin, Xiaoyun
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Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Qin, Xiaoyun
[1
,2
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Li, Dongyang
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Zhengzhou Univ Light Ind, Sch Elect & Informat Engn, Zhengzhou 450000, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Li, Dongyang
[3
]
Qin, Xiaomei
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机构:
Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Qin, Xiaomei
[1
]
Chen, Fenghua
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机构:
Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Chen, Fenghua
[1
]
Guo, Huishi
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Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Guo, Huishi
[1
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Gui, Yanghai
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Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Gui, Yanghai
[1
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Zhao, Jianbo
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Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Zhao, Jianbo
[1
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Jiang, Liying
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Zhengzhou Univ Light Ind, Sch Elect & Informat Engn, Zhengzhou 450000, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Jiang, Liying
[3
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Luo, Dan
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机构:
Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R ChinaZhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
Luo, Dan
[2
]
机构:
[1] Zhengzhou Univ Light Ind, Sch Mat & Chem Engn, Zhengzhou, Peoples R China
[2] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R China
[3] Zhengzhou Univ Light Ind, Sch Elect & Informat Engn, Zhengzhou 450000, Peoples R China
Acute myocardial infarction (AMI) is a major cause of cardiovascular disease-related death. It is essential for patients with cardiovascular disease to receive an early diagnosis of AMI. The most popular technique for the early detection of AMI is the use of biosensors to monitor the concentration of pertinent biomarkers, such as cardiac troponin I (cTnI), in the blood. The electrochemical detection methods hold great promise because of their simplicity, miniaturization, ease of integration, high sensitivity, and rapid response. The prime motive of this review is to present a comprehensive understanding of the pros and cons of methodologies employed for the electrochemical approaches toward the detection of cTnI. A detailed summary is provided for the immunosensors, aptamer sensors, molecular imprinting sensors, and peptide sensors based on various affinity elements. We enumerate the modified electrode materials for electrochemical sensors as well as popular detection techniques. Furthermore, this paper reviews some recent significant advances in point-of-care assays for rapid, accurate detection of cTnI as a smart integrated device for home monitoring. The accumulation of knowledge about these functions will lead to new insights into and concepts for the design of portable miniature sensors for cardiovascular patients at risk of AMI. It is anticipated that the interdisciplinary collaboration can bring more enlightenment to the progress of cardiac biomarkers sensor in the future. This review presents a comprehensive understanding of the pros and cons of methodologies used for the electrochemical approaches for the detection of cTnI. A detailed summary is provided for the immunosensors, aptamer sensors, molecular imprinting sensors, and peptide sensors based on different affinity elements. Furthermore, this paper also reviews some recent significant advances in point-of-care assays for rapid and accurate detection of cTnI as an intelligent integrated device for home monitoring. image
机构:National Chiao Tung University,Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio
Shih-Mein Chang
Sathyadevi Palanisamy
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机构:National Chiao Tung University,Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio
Sathyadevi Palanisamy
Tung-Ho Wu
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机构:National Chiao Tung University,Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio
Tung-Ho Wu
Chiao-Yun Chen
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机构:National Chiao Tung University,Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio
Chiao-Yun Chen
Kai-Hung Cheng
论文数: 0引用数: 0
h-index: 0
机构:National Chiao Tung University,Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio
Kai-Hung Cheng
Chen-Yi Lee
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机构:National Chiao Tung University,Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio
Chen-Yi Lee
Shyng-Shiou F. Yuan
论文数: 0引用数: 0
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机构:National Chiao Tung University,Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio
Shyng-Shiou F. Yuan
Yun-Ming Wang
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机构:National Chiao Tung University,Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio
机构:
Natl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, TaiwanNatl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan
Chang, Shih-Mein
Palanisamy, Sathyadevi
论文数: 0引用数: 0
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机构:
Natl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, TaiwanNatl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan
Palanisamy, Sathyadevi
Wu, Tung-Ho
论文数: 0引用数: 0
h-index: 0
机构:
Vet Gen Hosp, Dept Surg, Div Cardiovasc Surg, Kaohsiung 813, Taiwan
Vet Gen Hosp, Dept Crit Care Med, Div Surg Crit Care, Kaohsiung 813, TaiwanNatl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan
Wu, Tung-Ho
Chen, Chiao-Yun
论文数: 0引用数: 0
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机构:
Kaohsiung Med Univ, Dept Radiol, Coll Med, Fac Med, Kaohsiung, Taiwan
Kaohsiung Med Univ Hosp, Dept Med Imaging, Kaohsiung, TaiwanNatl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan
Chen, Chiao-Yun
Cheng, Kai-Hung
论文数: 0引用数: 0
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机构:
Kaohsiung Med Univ Hosp, Div Cardiol, Dept Internal Med, Kaohsiung, TaiwanNatl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan
Cheng, Kai-Hung
Lee, Chen-Yi
论文数: 0引用数: 0
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机构:
Natl Chiao Tung Univ, Dept Elect Engn, Hsinchu, TaiwanNatl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan
Lee, Chen-Yi
Yuan, Shyng-Shiou F.
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机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Translat Res Ctr, Kaohsiung, Taiwan
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Obstet & Gynecol, Kaohsiung, Taiwan
Kaohsiung Med Univ, Fac & Coll Med, Kaohsiung, TaiwanNatl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan
Yuan, Shyng-Shiou F.
Wang, Yun-Ming
论文数: 0引用数: 0
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机构:
Natl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan
Kaohsiung Med Univ, Ctr Canc Res, Dept Biomed Sci & Environm Biol, Kaohsiung 807, TaiwanNatl Chiao Tung Univ, Dept Biol Sci & Technol, Inst Mol Med & Bioengn, Ctr Intelligent Drug Syst & Smart Biodevices IDS2, 75 Bo Ai St, Hsinchu 300, Taiwan