Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2-313.2 K

In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2 K to 313.2 K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, JouybanAcree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including AG degrees, oH degrees, AS degrees, and TAS degrees. These properties offer valuable insights into the energetic aspects of the dissolution process and were calculated based on the van't Hoff equation. (c) 2024 Acade<acute accent>mie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.