Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells

被引：1

作者：

Simon, Malte ^{[1
,2
,3
,4
]}

Stueve, Philipp ^{[3
,4
]}

Schmidleithner, Lisa ^{[3
,4
]}

Bittner, Sebastian ^{[3
,4
]}

Beumer, Niklas ^{[1
,5
,6
,7
]}

Strieder, Nicholas ^{[2
,3
]}

Schmidl, Christian ^{[3
]}

Pant, Asmita ^{[3
,4
]}

Gebhard, Claudia ^{[3
]}

Eigenberger, Andreas ^{[8
]}

Rehli, Michael ^{[3
,9
]}

Prantl, Lukas ^{[8
]}

Hehlgans, Thomas ^{[3
,4
]}

Brors, Benedikt ^{[1
,2
,10
,11
,12
]}

Imbusch, Charles D. ^{[1
]}

Delacher, Michael ^{[13
,14
]}

Feuerer, Markus ^{[3
,4
]}

机构：

[1] German Canc Res Ctr, Div Appl Bioinformat, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Fac Biosci, D-69120 Heidelberg, Germany

[3] Leibniz Inst Immunotherapy, D-93053 Regensburg, Germany

[4] Univ Regensburg, Chair Immunol, D-93053 Regensburg, Germany

[5] Univ Med Ctr Mannheim, DKFZ Hector Canc Inst, D-68167 Mannheim, Germany

[6] DKFZ, Div Personalized Med Oncol, D-69120 Heidelberg, Germany

[7] Heidelberg Univ, Univ Hosp Mannheim, Med Fac Mannheim, Dept Personalized Oncol, D-68167 Mannheim, Germany

[8] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany

[9] Univ Hosp Regensburg, Dept Internal Med 3, D-93053 Regensburg, Germany

[10] Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany

[11] DKFZ, German Canc Consortium DKTK, D-69120 Heidelberg, Germany

[12] Heidelberg Univ, Med Fac Heidelberg, D-69120 Heidelberg, Germany

[13] Univ Med Ctr Mainz, Inst Immunol, D-55131 Mainz, Germany

[14] Univ Med Ctr Mainz, Res Ctr Immunotherapy, D-55131 Mainz, Germany

来源：

IMMUNITY | 2024年 / 57卷 / 08期

基金：

欧洲研究理事会;

关键词：

REGULATORY T-CELLS; TRANSCRIPTION-FACTOR; R PACKAGE; POPULATION; BATF; DIFFERENTIATION; HETEROGENEITY; ACCUMULATION; ENHANCERS; LINEAGE;

D O I：

10.1016/j.immuni.2024.06.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations is unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45+ + immune cells from colon, skin, adipose tissue, and spleen. We identified features of organ-specific tissue adaptation across different immune cells. Focusing on tissue Treg cells, we found conservation of the Treg tissue adaptation program in other tissue-localized immune cells, such as amphiregulin-producing T helper (Th)17 cells. Accessible TEs can act as regulatory elements, but their contribution to tissue adaptation is not understood. TE landscape analysis revealed an enrichment of specific transcription factor binding motifs in TE regions within accessible chromatin peaks. TEs, specifically from the LTR family, were located in enhancer regions and associated with tissue adaptation. These findings broaden our understanding of immune tissue residency and provide an important step toward organ-specific immune interventions.

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页数：30

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