Advances in Non-Small Cell Lung Cancer: Current Insights and Future Directions

被引:8
|
作者
Garg, Pankaj [1 ]
Singhal, Sulabh [2 ]
Kulkarni, Prakash [3 ]
Horne, David [4 ,5 ]
Malhotra, Jyoti [3 ]
Salgia, Ravi [3 ]
Singhal, Sharad S. [3 ]
机构
[1] GLA Univ, Dept Chem, Mathura 281406, Uttar Pradesh, India
[2] Drexel Univ, Dept Internal Med, Coll Med, Philadelphia, PA 19104 USA
[3] Beckman Res Inst City Hope, Comprehens Canc Ctr & Natl Med Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA 91010 USA
[4] Beckman Res Inst City Hope, Comprehens Canc Ctr, Dept Mol Med, Duarte, CA 91010 USA
[5] Natl Med Ctr, Duarte, CA 91010 USA
基金
美国国家卫生研究院;
关键词
non-small cell lung cancer (NSCLC); lung cancer diagnosis; targeted therapies; genetic profiling; therapeutic resistance; CAR-T cell therapy; MODULATED RADIATION-THERAPY; INHIBITORS; DIAGNOSIS; EGFR; REARRANGEMENTS; EPIDEMIOLOGY; MANAGEMENT; RESISTANCE; MUTATIONS; MRI;
D O I
10.3390/jcm13144189
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The leading cause of cancer deaths worldwide is attributed to non-small cell lung cancer (NSCLC), necessitating a continual focus on improving the diagnosis and treatment of this disease. In this review, the latest breakthroughs and emerging trends in managing NSCLC are highlighted. Major advancements in diagnostic methods, including better imaging technologies and the utilization of molecular biomarkers, are discussed. These advancements have greatly enhanced early detection and personalized treatment plans. Significant improvements in patient outcomes have been achieved by new targeted therapies and immunotherapies, providing new hope for individuals with advanced NSCLC. This review discusses the persistent challenges in accessing advanced treatments and their associated costs despite recent progress. Promising research into new therapies, such as CAR-T cell therapy and oncolytic viruses, which could further revolutionize NSCLC treatment, is also highlighted. This review aims to inform and inspire continued efforts to improve outcomes for NSCLC patients globally, by offering a comprehensive overview of the current state of NSCLC treatment and future possibilities.
引用
收藏
页数:24
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