Development of Axially Chiral Pyridylidene Amine Ligands and their Application in Pd-Catalyzed Enantioselective Allylic Substitution

被引：0

作者：

Chen, Zhikang ^{[1
]}

Liu, Jiahao ^{[1
]}

Ou, Weiying ^{[1
]}

Kato, Terumasa ^{[1
,2
,3
]}

Wang, Zhe ^{[1
,2
]}

Chen, Yong ^{[4
]}

Liu, Yan ^{[1
,2
]}

Maruoka, Keiji ^{[1
,2
,3
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China

[2] Guangdong Univ Technol, Guangdong Prov Key Lab Plant Resources Biorefinery, Guangzhou 510006, Peoples R China

[3] Kyoto Univ, Grad Sch Pharmaceut Sci, Lab Organocatalyt Chem, Sakyo, Kyoto 6068501, Japan

[4] China Natl Anal Ctr, Guangzhou 510070, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 17期

基金：

中国国家自然科学基金;

关键词：

BIS(OXAZOLINE) LIGANDS; BOND STANNYLATION; SN BONDS; PALLADIUM; COMPLEXES; ALKYLATION; DESIGN; SWITCH;

D O I：

10.1021/acs.joc.4c01334

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel axially chiral pyridylidene amine (PYE) ligands has been developed, and their catalytic capability has been demonstrated in various highly efficient and enantioselective Pd-catalyzed asymmetric allylic substitutions. A density-functional theory (DFT) study explains the preferential enantiocontrol in the key transition states of the axially chiral PYE ligand-promoted Pd-catalyzed allylic alkylation.

引用

页码：12800 / 12811

页数：12

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