A comparative study of auditory and non-auditory characteristics of congenital, early, and late-onset auditory neuropathy spectrum disorder

被引:0
|
作者
Nisha, Kavassery Venkateswaran [1 ,2 ]
Barman, Animesh [1 ]
Prabhu, Prashanth [1 ]
机构
[1] All India Inst Speech & Hearing AIISH, Dept Audiol, Naimisham Campus, Manasagangotri 570006, Mysore, India
[2] All India Inst Speech & Hearing, Ctr Hearing Sci, Mysuru, India
来源
EGYPTIAN JOURNAL OF OTOLARYNGOLOGY | 2024年 / 40卷 / 01期
关键词
Congenital ANSD; Auditory neuropathy; Late-onset ANSD; Auditory profiling; Discriminant analyses; Behavioral and electrophysiological tests; CHILDREN; CONSEQUENCES; INDIVIDUALS; MUTATIONS; SYNCHRONY; DIAGNOSIS;
D O I
10.1186/s43163-024-00675-5
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
BackgroundThe study explored the differences in audiological and non-audiological characteristics between congenital, early-onset, and late-onset auditory neuropathy spectrum disorder (ANSD). Ninety-five individuals diagnosed with ANSD were included in the study. They were divided into three groups congenital ANSD-children (30 individuals, 60 ears), adults with early-onset ANSD (30 individuals, 56 ears), and adults with late-onset ANSD (35 individuals, 62 ears). The non-audiological characteristics (gender, laterality, and risk factors) and audiological characteristics (behavioral and electrophysiological measures) were compared between the three groups.ResultsDiscriminant analyses showed that the pure tone average, audiogram configuration, and speech thresholds were the best auditory predictors of onset-based group differences in ANSD (congenital and early-onset versus late-onset ANSD). While the congenital and early-onset group showed poorer pure-tone and speech thresholds, along with flat configuration, the late-onset group demonstrated relatively better thresholds and other configurations (rising, tent-shaped, cookie-bite). In addition, long latency responses were delayed or absent in children with congenital ANSD, indicative of onset coding deficits at the cortical level.ConclusionsThe study highlights the audiological differences between congenital, early-, and late-onset ANSD groups. These differences could be because of variations in etiology, pathophysiology, site of lesion, or genetic variability between the groups, which needs to be explored further.
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页数:16
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