Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors

被引：2

作者：

Farley, Morgan J. ^{[1
,2
,3
]}

Boytar, Alexander N. ^{[2
]}

Adlard, Kirsten N. ^{[2
]}

Salisbury, Chloe E. ^{[2
]}

Hart, Nicolas H. ^{[1
,3
,4
,5
,6
]}

Schaumberg, Mia A. ^{[2
,7
,8
,9
]}

Jenkins, David G. ^{[2
,7
,8
,10
]}

Skinner, Tina L. ^{[1
,2
,7
,11
]}

机构：

[1] Univ Technol Sydney UTS, INSIGHT Res Inst, Fac Hlth, Human Performance Res Ctr, Sydney, NSW, Australia

[2] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia

[3] Queensland Univ Technol QUT, Fac Hlth, Canc & Palliat Care Outcomes Ctr, Brisbane, Qld, Australia

[4] Flinders Univ S Australia, Caring Futures Inst, Coll Nursing & Hlth Sci, Adelaide, SA, Australia

[5] Edith Cowan Univ, Exercise Med Res Inst, Sch Med & Hlth Sci, Perth, WA, Australia

[6] Univ Notre Dame Australia, Inst Hlth Res, Perth, WA, Australia

[7] Univ Sunshine Coast, Sch Hlth, Sunshine Coast, Qld, Australia

[8] Sunshine Coast Hosp & Hlth Serv, Sunshine Coast Hlth Inst, Birtinya, Qld, Australia

[9] Univ New England, Manna Inst, Armidale, NSW, Australia

[10] Swansea Univ, Appl Sports Sci Technol & Med Res Ctr, Swansea, Wales

[11] Univ New South Wales, Sch Hlth Sci, Sydney, Australia

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2024年 / 602卷 / 20期

关键词：

exercise; high-intensity interval training; immunology; interleukins; myokines; neoplasm; SKELETAL-MUSCLE; PHYSICAL-ACTIVITY; CYTOKINES; PATHWAYS; HEALTH;

D O I：

10.1113/JP286043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

figure legend This study demonstrated that high-intensity interval exercise is a sufficient dose of exercise to significantly increase IL-15, IL-6, IL-10 and IL-1ra concentrations immediately after exercise. However, there was no significant influence of training on this response. Myokines including IL-15 and IL-6 have been previously associated with the suppression of cancer growth in pre-clinical and in vitro models. Therefore, it can be postulated that repeated bouts of high-intensity exercise may, at least in part, be a key mechanism behind the anti-oncogenic effect of exercise and 4x4 high-intensity interval exercise is sufficient stimulus to elicit this myokine response. image

引用

页码：5203 / 5215

页数：13

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