Synthesis and antihyperglycemic activity of phenolic C-glycosides

被引：36
|
作者：
Rawat, Preeti [1 ]
Kumar, Manmeet [1 ]
Rahuja, Neha [2 ]
Srivastava, Daya Shankar Lal [2 ]
Srivastava, Arvind Kumar [2 ]
Maurya, Rakesh [1 ]
机构：
[1] CSIR, Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India
[2] CSIR, Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 01期
关键词：
Phenolic C-glycosides; Antihyperglycemic activity; STZ; DEPENDENT DIABETES-MELLITUS; FLAVONOIDS;
D O I：
10.1016/j.bmcl.2010.11.031
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Various phenolic C-glycosides were evaluated for their in vitro and in vivo antihyperglycemic activity employing glucose uptake by rat muscle cell lines (L-6) and low dosed-streptozotocin-induced diabetic rats, respectively. Some of phenolic C-glycosides were isolated from Pterocarpus marsupium and Ulmus wallichiana and other were synthesized by unprotected sugar and phloroacetophenone using Sc(OTf)(3) in aqueous ethanol. Eight among tested compounds showed significant lowering of blood glucose level on low dosed-streptozotocin-induced diabetic rats. The compound 24 lowered the blood glucose levels by 34.9% and 33.6% during 0-5 h and 0-24 h, respectively, at the dose of 25 mg/kg body weight which is comparable to standard antidiabetic drug metformin. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：228 / 233
页数：6
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