A Narrative Review of Post-traumatic Neuroinflammation: Relevance to Pediatrics

This is a narrative review that explores the complex interaction between post-traumatic neuroinflammation and its importance in pediatric traumatic brain injuries (TBIs). For immediate and long-term consequences of TBI, neuroinflammation, manifested by activation of microglia and astrocytes, secretion of pro- inflammatory cytokines, as well as breakdown of the blood-brain barrier, are critical factors. While inflammation is an essential part of the brain's repair systems, excessive or prolonged neuroinflammation can lead to more significant neuronal damage, which, in turn, causes persistent cognitive and behavioral deficits over time. In this regard, the paper synthesizes existing evidence concerning molecular and cellular mechanisms that underlie neuroinflammation in relation to TBI among children, paying attention to age disparities in inflammatory response and their implications for treatment and recovery. Furthermore, it explores how targeted anti-inflammatory therapies are highly likely to improve outcomes for pediatric patients. The outcomes emphasize that there is a need for a more comprehensive understanding of child neuroinflammatory processes and age-specific therapeutic approaches aimed at lessening the effects' negative impacts after brain injury occurs.