Deciphering the Gut-Liver Axis: A Comprehensive Scientific Review of Non-Alcoholic Fatty Liver Disease

被引：0

作者：

Singh, Samradhi ^{[1
]}

Kriti, Mona ^{[1
]}

Catanzaro, Roberto ^{[2
]}

Marotta, Francesco ^{[3
]}

Malvi, Mustafa ^{[4
]}

Jain, Ajay ^{[4
]}

Verma, Vinod ^{[5
]}

Nagpal, Ravinder ^{[6
]}

Tiwari, Rajnarayan ^{[1
]}

Kumar, Manoj ^{[1
]}

机构：

[1] ICMR Natl Inst Res Environm Hlth, Bhopal Bypass Rd, Bhopal 462030, India

[2] Univ Catania, Univ Hosp Policlin G Rodol, Dept Clin & Expt Med, Internal Med Unit,Gastroenterol & Hepatol Serv, I-95123 Catania, Italy

[3] ReGenera Res Grp Aging Intervent, I-20144 Milan, Italy

[4] Choithram Hosp & Res Ctr Indore, Indore 452014, India

[5] Sanjay Gandhi Postgrad Inst Med Sci, Stem Cell Res Ctr, Dept Hematol, Lucknow 226014, India

[6] Florida State Univ, Coll Hlth & Human Sci, Dept Nutr & Integrat Physiol, Tallahassee, FL 32306 USA

来源：

LIVERS | 2024年 / 4卷 / 03期

关键词：

metabolic disorder; NAFLD; gut-liver axis; gut microbiome; hepatic steatosis; probiotics; ANTIBIOTIC-ASSOCIATED DIARRHEA; INTESTINAL PERMEABILITY; ADIPOSE-TISSUE; OBESE MICE; BILE-ACIDS; MICROBIOTA; PROBIOTICS; CHILDREN; HEALTH; INFLAMMATION;

D O I：

10.3390/livers4030032

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant global health issue. The condition is closely linked to metabolic dysfunctions such as obesity and type 2 diabetes. The gut-liver axis, a bidirectional communication pathway between the liver and the gut, plays a crucial role in the pathogenesis of NAFLD. This review delves into the mechanisms underlying the gut-liver axis, exploring the influence of gut microbiota, intestinal permeability, and inflammatory pathways. This review also explores the potential therapeutic strategies centered on modulating gut microbiota such as fecal microbiota transplantation; phage therapy; and the use of specific probiotics, prebiotics, and postbiotics in managing NAFLD. By understanding these interactions, we can better comprehend the development and advancement of NAFLD and identify potential therapeutic targets.

引用

页码：435 / 454

页数：20

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