Deoxygenative alkynylation of amides via C=0 O bond cleavage

被引：0
|
作者：
Chen, Lan [1 ]
Zhou, Wei [1 ]
Zhang, Jianwen [1 ]
Ding, Yimin [1 ]
Szostak, Michal [2 ]
Liu, Chengwei [1 ]
机构：
[1] Shanghai Univ, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China
[2] Rutgers State Univ, Dept Chem, 73 Warren St, Newark, NJ 07102 USA
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 64期
关键词：
C-H ACTIVATION; GRIGNARD; SILYLATION; REDUCTION; REAGENTS; LACTAMS; AMINE; IMINE; 1ST;
D O I：
10.1039/d4cc02316a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel deoxygenative alkynylation of amides promoted by a synergistic action of a divalent rare-earth element and a transition metal has been developed. In this method, alpha-alkynyl substituted amines are synthesized from unactivated amides and alkynes in a single transformation. Broad substrate scope and excellent selectivity for C=O cleavage has been demonstrated. This approach represents a general method for the construction of versatile alpha-alkynyl substituted amines from unactivated amide bonds.
引用
收藏
页码：8454 / 8457
页数：4
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