Thyroid hormones for euthyroid patients with simple goiter growing over time: a survey of European thyroid specialists

被引：0

作者：

Papini, Enrico ^{[1
]}

Attanasio, Roberto ^{[2
]}

Zarkovic, Milos ^{[3
]}

Nagy, Endre Vezekenyi ^{[4
]}

Negro, Roberto ^{[5
]}

Perros, Petros ^{[6
]}

Galofre, Juan Carlos ^{[7
,8
]}

Cohen, Chagit Adler ^{[9
]}

Akarsu, Ersin ^{[10
]}

Alevizaki, Maria ^{[11
]}

Ayvaz, Goksun ^{[12
]}

Bednarczuk, Tomasz ^{[13
]}

Beleslin, Biljana Nedeljkovic ^{[3
]}

Berta, Eszter ^{[4
]}

Bodor, Miklos ^{[4
]}

Borissova, Anna Maria ^{[14
]}

Boyanov, Mihail ^{[15
]}

Buffet, Camille ^{[16
]}

Burlacu, Maria-Cristina ^{[17
]}

Ciric, Jasmina ^{[3
]}

Diez, Juan J. ^{[18
,19
,20
]}

Dobnig, Harald ^{[21
,22
]}

Fadeyev, Valentin ^{[23
]}

Field, Benjamin C. T. ^{[24
]}

Fuehrer-Sakel, Dagmar ^{[25
]}

Hakala, Tommi ^{[26
]}

Jiskra, Jan ^{[27
]}

Kopp, Peter Andreas ^{[28
]}

Krebs, Michael ^{[29
]}

Krsek, Michal ^{[27
]}

Lantz, Mikael ^{[30
]}

Lazurova, Ivica ^{[31
]}

Leenhardt, Laurence ^{[16
]}

Luchytskiy, Vitaliy ^{[32
]}

Puga, Francisca Marques ^{[33
]}

McGowan, Anne ^{[34
]}

Melo, Miguel ^{[35
]}

Metso, Saara ^{[36
]}

Moran, Carla ^{[37
,38
]}

Morgunova, Tatyana ^{[23
]}

Niculescu, Dan Alexandru ^{[39
]}

Peric, Bozidar ^{[40
]}

Planck, Tereza ^{[30
]}

Robenshtok, Eyal ^{[41
,42
]}

Rosselet, Patrick Olivier ^{[43
]}

Ruchala, Marek ^{[44
]}

Riis, Kamilla Ryom ^{[45
]}

Shepelkevich, Alla ^{[46
]}

Tronko, Mykola ^{[47
]}

Unuane, David ^{[48
]}

机构：

[1] Regina Apostolorum Hosp, Dept Endocrinol & Metab, Rome, Italy

[2] Sci Comm Assoc Med Endocrinol, Milan, Italy

[3] Univ Belgrade, Fac Med, Belgrade, Serbia

[4] Univ Debrecen, Fac Med, Dept Med, Div Endocrinol, Debrecen, Hungary

[5] Osped Fazzi, Div Endocrinol, Lecce, Italy

[6] Newcastle Univ, Inst Translat & Clin Res, Newcastle Upon Tyne, England

[7] Clin Univ Navarra, Dept Endocrinol, Pamplona, Spain

[8] Inst Invest Sanit Navarra, Pamplona, Spain

[9] Tel Aviv Univ, Rabin Med Ctr, Tel Aviv, Israel

[10] Gaziantep Univ, Fac Med, Dept Internal Med, Div Endocrinol, Gaziantep, Turkiye

[11] Natl & Kapodistrian Univ Athens, Alexandra Hosp, Diabet Ctr, Sch Med,Dept Clin Therapeut, Athens, Greece

[12] Koru Ankara Hosp, Dept Endocrinol & Metab, Cankaya, Ankara, Turkiye

[13] Med Univ Warsaw, Dept Internal Med & Endocrinol, Warsaw, Poland

[14] Sofia Univ St Kliment Ohridski, Univ Hosp Sofiamed, Med Fac, Clin Endocrinol, Sofia, Bulgaria

[15] Med Univ Sofia, Univ Hosp Alexandrovska, Dept Internal Med, Clin Endocrinol & Metab, Sofia, Bulgaria

[16] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, GRC Thyroid Tumors,GRC 16,Thyroid Pathol & Endocri, Paris, France

[17] Catholic Univ Louvain, Dept Endocrinol Diabetol & Nutr, Clin Univ St Luc, Brussels, Belgium

[18] Hosp Univ Puerta de Hierro Majadahonda Majadahonda, Dept Endocrinol, Madrid, Spain

[19] Inst Invest Sanitaria Puerta de Hierro Segovia Ara, Madrid, Spain

[20] Univ Autonoma Madrid, Dept Med, Madrid, Spain

[21] Thyroid & Osteoporosis Praxis, Kumberg, Austria

[22] Thyroid Practice Radiofrequency Ablat, Vienna, Austria

[23] IM Sechenov First Moscow State Med Univ Sechenov, NV Sklifosovsky Inst Clin Med, Dept Endocrinol 1, Moscow, Russia

[24] Univ Surrey, Fac Hlth & Med Sci, Sect Clin Med, Guildford, Surrey, England

[25] Univ Duisburg Essen, Univ Hosp Essen, Dept Endocrinol Diabet & Metab, Essen, Germany

[26] Tampere Univ Hosp, Dept Surg, Tampere, Finland

[27] Charles Univ Prague, Gen Univ Hosp, Fac Med 1, Dept Med 3, Prague, Czech Republic

[28] Univ Lausanne, Div Endocrinol Diabet & Metab, Lausanne, Switzerland

[29] Med Univ Vienna, Div Endocrinol & Metab, Internal Med 3, Vienna, Austria

[30] Skane Univ Hosp, Dept Endocrinol, Malmo, Sweden

[31] PJ Safarik Univ Kosice, Med Fac, Dept Internal Med 1, Kosice, Slovakia

[32] Natl Acad Med Sci Ukraine, Inst Endocrinol & Metab, Dept Reprod Endocrinol, Kyiv, Ukraine

[33] Ctr Hosp Univ Santo Antonio, Endocrinol Diabet & Metab Serv, Porto, Portugal

[34] Tallaght Univ Hosp, Robert Graves Inst, Dublin, Ireland

[35] Univ Coimbra, Med Fac, Dept Endocrinol Diabet & Metab, Coimbra, Portugal

[36] Tampere Univ Hosp, Dept Endocrinol, Tampere, Finland

[37] Beacon Hosp, Diabet & Endocrinol Sect, Dublin, Ireland

[38] Univ Coll Dublin, Sch Med, Dublin, Ireland

[39] Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest, Romania

[40] Clin Hosp Ctr Sisters Mercy, Dept Endocrinol Diabet & Metabol Dis Mladen Sekso, Zagreb, Croatia

[41] Tel Aviv Univ, Beilinson Hosp, Endocrinol & Metab Inst, Sackler Fac Med,Thyroid Canc Serv, Petah Tiqwa, Israel

[42] Tel Aviv Univ, Sackler Fac Med, Davidoff Canc Ctr, Rabin Med Ctr, Petah Tiqwa, Israel

[43] Cabinet Med 2, Rue Bellefontaine, Lausanne, Switzerland

[44] Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Med, Poznan, Poland

[45] Odense Univ Hosp, Dept Endocrinol, Odense, Denmark

[46] Belarusian State Med Univ, Dept Endocrinol, Minsk, BELARUS

[47] Ukraine Acad Med Sci, VP Komisarenko Inst Endocrinol & Metab, Kyiv, Ukraine

[48] Vrije Univ Brussel, UZ Brussel, Dept Internal Med & Endocrinol, Brussels, Belgium

[49] Ruhr Univ Bochum, Acad Teaching Hosp, Knappschaftskrankenhaus Recklinghausen, Dept Med 1,Klinikum Vest GmbH, Recklinghausen, Germany

[50] Heidelberg Univ, Med Fac Mannheim, Med Dept 5, Div Endocrinol & Diabet, Mannheim, Germany

来源：

ENDOCRINE | 2025年 / 87卷 / 01期

关键词：

Survey; Goiter; Thyroid hormone; Levothyroxine; TSH-suppressive therapy; NONTOXIC MULTINODULAR GOITER; LEVOTHYROXINE SUPPRESSIVE THERAPY; MAJOR OSTEOPOROTIC FRACTURES; PROSPECTIVE RANDOMIZED-TRIAL; EXCESS MORTALITY; UNDER-TREATMENT; NODULAR GOITER; MANAGEMENT; HYPOTHYROIDISM; ENDOCRINOLOGISTS;

D O I：

10.1007/s12020-024-04002-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Treatment of simple goiter (SG) growing over time with thyroid hormone (TH) therapy is discouraged by international guidelines. Purpose To ascertain views of European thyroid specialists about TH treatment for euthyroid patients with growing SG and explore associations with management choice. MethodsOnline survey on the use of TH for growing SG among thyroid experts from 28 European countries. Results The response rate was 31.5% (5430/17,247). Most respondents were endocrinologists. Twenty-eight percent asserted that TH therapy may be indicated in euthyroid patients with a growing SG. National and regional differences were noted, from 7% of positive responses in The Netherlands to 78% in Czech Republic (p < 0.0001). TH was more frequently prescribed by respondents over 40 years old (OR 1.77, 2.13, 2.41 if 41-50, 51-60, >60, respectively), and working in areas of former iodine insufficiency (OR 1.24, 95% CI 1.03-1.50). TH was less frequently prescribed by endocrinologists (OR 0.77, 95% CI 0.62-0.94) and respondents working in Southern Europe (OR 0.40, 95% CI 0.33-0.48), Northern Europe (OR 0.28, 95% CI 0.22-0.36) and Western Asia (OR 0.16, 95% CI 0.11-0.24) compared to Western Europe. Associations with respondents' sex, country, availability of national thyroid guidelines, and gross national income per capita were absent or weak. Conclusions Almost a third of European thyroid specialists support treating SG with TH, contrary to current guidelines and recommendations. This calls for urgent attention.

引用

页码：262 / 272

页数：11

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