共 50 条
The impact of high polymerization inulin on body weight reduction in high-fat diet-induced obese mice: correlation with cecal Akkermansia
被引:0
|作者:
Gan, Liping
[1
]
Zhao, Yifeng
[1
]
Zhang, Zongbao
[1
]
Zhao, Chenkai
[1
]
Li, Jiake
[1
]
Jia, Qingyu
[1
]
Shi, Yusu
[1
]
Wang, Peng
[1
]
Guo, Linna
[1
]
Qiao, Hanzhen
[1
]
Cui, Yaoming
[1
]
Wang, Jinrong
[1
]
机构:
[1] Henan Univ Technol, Sch Bioengn, Zhengzhou, Peoples R China
基金:
中国国家自然科学基金;
关键词:
inulin;
polymerization degree;
obesity;
gut microbiota;
high fat diet;
Akkermansia;
LIPID-METABOLISM;
GUT MICROBIOTA;
DIVERSITY;
D O I:
10.3389/fmicb.2024.1428308
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Obesity presents a significant public health challenge, demanding effective dietary interventions. This study employed a high-fat diet-induced obesity mouse model to explore the impacts of inulin with different polymerization degrees on obesity management. Our analysis reveals that high-degree polymerization inulin (HDI) exhibited a significantly higher oil binding capacity and smaller particle size compared to low-degree polymerization inulin (LDI) (p < 0.05). HDI was more effective than LDI in mitigating body weight gain in high-diet induced obese mice, although neither LDI nor HDI affected blood sugar levels when compared to the high-fat diet control group (p < 0.05). Both HDI and LDI administrations reduced liver weight and enhanced brown adipose tissue thermogenesis compared to the high-fat diet induced control group (p < 0.05). Additionally, HDI suppressed hepatic lipogenesis, resulting in a further reduction in liver triglycerides compared to the high-fat diet-induced obese mice (p < 0.05). Notably, HDI improved gut health by enhancing intestinal morphology and modulating gut microbiota structure. HDI administration notably increased the relative abundance of cecal Akkermansia, a gut microbe associated with improved metabolic health, while LDI showed limited efficacy (p < 0.05 and p > 0.05, respectively). These findings underscore the importance of the structural properties of inulin in its potential to combat obesity and highlight the strategic use of inulin with varying polymerization degrees as a promising dietary approach for obesity management, particularly in its influence on gut microbiota composition and hepatic lipid metabolism regulation.
引用
收藏
页数:16
相关论文