Mitigative Effects of Topical Norfloxacin on an Imiquimod-Induced Murine Model of Psoriasis

被引:9
|
作者
Ridha-Salman, Hayder [1 ]
Shihab, Elaf Mahmood [2 ]
Hasan, Hasanain Kamil [1 ]
Abbas, Alaa Hamza [1 ]
Khorsheed, Shan Mohammed [3 ]
Fakhri, Salar Ayad [2 ]
机构
[1] Al Mustaqbal Univ, Coll Pharm, Dept Pharmacol, Hillah 51001, Babylon, Iraq
[2] Al Esraa Univ, Coll Pharm, Dept Pharm, Baghdad 964, Iraq
[3] Al Nahrain Univ, Coll Med, Dept Pharmacol, Baghdad 964, Iraq
关键词
imiquimod-induced psoriasis; inflammatory dermatoses; immune-mediated diseases; antipsoriatic therapy; fluoroquinolones; norfloxacin; OINTMENT DOSAGE FORM; NF-KAPPA-B; VITAMIN-D; PROINFLAMMATORY CYTOKINES; PHENOLIC EXTRACT; OXIDATIVE STRESS; INDUCED COLITIS; HUMAN MONOCYTES; CO-DELIVERY; TNF-ALPHA;
D O I
10.1021/acsptsci.4c00152
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Psoriasis is a chronic, inflammatory dermatosis characterized by thickened, reddened, and scaly skin lesions. Norfloxacin is a fluoroquinolone antibiotic with enhanced antioxidant, anti-inflammatory, and immunomodulatory bioactivities. The aim of this study was to figure out the possible impact of topical norfloxacin on an imiquimod-induced model of psoriasis in mice. Thirty albino-type mice were split into five distinct groups of six animals each. The control group included healthy mice that had not received any treatment. The induction group was given the vehicle 2 h after the topical imiquimod, once daily for 8 days. Two hours after receiving topical imiquimod, the treatment groups including calcipotriol, norfloxacin 2.5%, and norfloxacin 5% were given topical ointments containing calcipotriol 0.005%, norfloxacin 2.5%, and norfloxacin 5%, for 8 days. Topical norfloxacin ointment significantly reduced the severity of imiquimod-exacerbated psoriatic lesions including erythema, shiny-white scaling, and acanthosis and fixed histological abnormalities. Furthermore, imiquimod-subjected mice treated with a higher concentration of norfloxacin ointment exhibited dramatically lower skin levels of inflammation-related biomarkers like IFN-gamma, TNF-alpha, IL-6, IL-17A, IL-23, and TGF-beta but higher levels of IL-10. They also demonstrated a notable decrease in angiogenesis parameters such as VEGF and IL-8, a substantial reduction in oxidative indicators like MDA and MPO, and a considerable rise in antioxidant enzymes like SOD and CAT. This study offers novel evidence that norfloxacin may assist in controlling inflammatory dermatoses like psoriasis by minimizing the severity of psoriatic plaques, correcting histological alterations, and diminishing the production of inflammatory, oxidative, and angiogenetic parameters.
引用
收藏
页码:2739 / 2754
页数:16
相关论文
共 50 条
  • [21] Complement C3 exacerbates skin inflammation in a murine model of imiquimod-induced psoriasis
    Giacomassi, C.
    Ling, G. S.
    Strid, J.
    Dazzi, F.
    Botto, M.
    IMMUNOLOGY, 2014, 143 : 120 - 120
  • [22] Imiquimod-induced extensive plaque psoriasis
    Abreu, Erica P.
    Schwan, Nicole V.
    Gontijo, Joao R. V.
    Bittencourt, Flavia V.
    INTERNATIONAL JOURNAL OF DERMATOLOGY, 2023, 62 (12) : E614 - E615
  • [23] Topical application of imatinib mesylate ameliorated psoriasis-like skin lesions in imiquimod-induced murine model via angiogenesis inhibition
    Hayakawa, Kazuma
    Maeda, Tatsuo
    Egusa, Chizu
    Okubo, Yukari
    Harada, Kazutoshi
    EXPERIMENTAL DERMATOLOGY, 2023, 32 (06) : 878 - 888
  • [24] The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model
    Wu, Shidi
    Zhao, Mengjie
    Sun, Yanhong
    Xie, Meng
    Le, Kehao
    Xu, Ming
    Huang, Changzheng
    LIFE SCIENCES, 2020, 241
  • [25] THE THERAPEUTIC EFFECT OF PLAG IN THE IMIQUIMOD-INDUCED PSORIASIS MICE MODEL
    Lee, Ha-Reum
    Yoon, Sun Young
    Yoon, Suk Ran
    Kim, Jae Wha
    INTERNAL MEDICINE JOURNAL, 2018, 48 : 23 - 24
  • [26] How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?
    Pischon, Hannah
    Radbruch, Moritz
    Ostrowski, Anja
    Schumacher, Fabian
    Hoenzke, Stefan
    Kleuser, Burkhard
    Hedtrich, Sarah
    Fluhr, Joachim W.
    Gruber, Achim D.
    Mundhenk, Lars
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (02) : 455 - 458
  • [27] Mast Cells participate in an imiquimod-induced mouse model of psoriasis
    Hao, Y.
    Che, D.
    Peng, B.
    Zheng, Y.
    He, L.
    Geng, S.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2020, 140 (07) : S8 - S8
  • [28] Examination of evaluation parameters in an Imiquimod-induced psoriasis mice model
    Yamazawa, Takumi
    Ushijima, Souta
    Nishiyama, Yuuichi
    Katayama, Seiichi
    Morizumi, Kousuke
    Nishi, Katsuhide
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2017, 133 (03) : S241 - S241
  • [29] Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis
    Fenix, Kevin
    Wijesundara, Danushka K.
    Cowin, Allison J.
    Grubor-Bauk, Branka
    Kopecki, Zlatko
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (19) : 1 - 13
  • [30] The alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation
    Ridha-Salman, Hayder
    Al-Zubaidy, Adeeb Ahmed
    Abbas, Alaa Hamza
    Hassan, Dhuha M.
    Malik, Samir A.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, : 2695 - 2715