Hyperammonemic encephalopathy induced by valproic acid

被引：0
|
作者：
Zhu, Qiuyu M. [1 ]
Singh, Amitosh K. [1 ]
Chang, Huai-En Rachel [1 ]
Konka, Sandeep A. [2 ]
机构：
[1] Kaiser Permanente Mid Atlantic States, Internal Med, Gaithersburg, MD 20879 USA
[2] Mid Atlantic Permanente Med Grp, Hosp Med, Rockville, MD USA
来源：
BMJ CASE REPORTS | 2024年 / 17卷 / 02期
关键词：
Unwanted effects; adverse reactions; Safety; Psychiatry (drugs and medicines); Healthcare improvement and patient safety; Drugs: CNS (not psychiatric); RISK-FACTORS; CARNITINE; LORAZEPAM;
D O I：
10.1136/bcr-2023-257144
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Valproate (VPA) is broad-spectrum antiepileptic drug. Several adverse reactions including hepatotoxicity, fetal risk and pancreatitis are well known and labelled as boxed warnings in the USA. One adverse reaction that is less well known but clinically significant for its severe morbidity is hyperammonemic encephalopathy. We present a case of woman with hyperammonemic encephalopathy following the initiation of VPA therapy; she had a favourable outcome with discontinuation of the drug and prompt treatment with lactulose and L-carnitine.
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页数：4
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