Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model - Novel findings

被引:8
|
作者
Almudaris, Sally Ayad [1 ]
Gatea, Fouad Kadhim [2 ]
机构
[1] Al Nahrain Univ, Coll Med, Dept Pharmacol, Baghdad, Iraq
[2] Al Nahrain Univ, Coll Med, Dept Pharmacol & Therapeut, Baghdad, Iraq
关键词
ivermectin; IL-10; TNF-a; VEGF; iL-17; psoriasis; imiquimod; histopathological study; SKIN INFLAMMATION; PLAQUE PSORIASIS; ANGIOGENESIS; PATHWAY; ROSACEA; DRUG; MICE;
D O I
10.3897/pharmacia.71.e114753
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Aim: investigate the possible anti-psoriatic effect of ivermectin in mice based on observational and histopathological outcomes and biomarkers. Methods: Sixty male Swiss Albino Mice were divided into six groups (Groups I-VI); each group contained ten mice with shaved dorsal skin. The clinical, pathological, and laboratory effects were measured. Results: Topical Ivermectin significantly decreased vascular endothelial growth factor levels. At the same time, the combination of ivermectin plus Clobetasol showed a more significant reduction in tumor necrosis factor-alpha (TNF-alpha) and Interleukin-17 (IL-17) levels. Regarding the Interleukin-10 (IL-10) level, the Ivermectin and Ivermectin/Clobetasol combination groups showed a significant increase in IL-10. Conclusion: Topical Ivermectin's anti-psoriasis activity increases IL-10 levels and could be used efficiently to alleviate psoriatic symptoms. Its combination treatment with Clobetasol holds promise for the management of psoriasis.
引用
收藏
页码:1 / 14
页数:14
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