Prediction of Acute Kidney Injury After Coronary Artery Bypass Graft From Preoperative Serum Uric Acid

Objective: To examine the association of an elevated level of uric acid (UA) in the bloodstream with an increased likelihood of acute kidney injury (AKI) following coronary artery bypass grafting (CABG) surgery. Design: Retrospective cohort study using a multivariate logistic regression model. Setting: Single institution. Participants: Recipients of CABG surgery. Intervention: None. Measurements and Main Results: A total of 761 individuals who underwent CABG were included in the study. The participants were categorized into 4 groups based on their UA level: Q1 group (UA <292.5 mu mol/L), Q2 group (292.5 <= UA <353 mu mol/L), Q3 group (353 <= UA < 423 mu mol/L), and Q4 group (UA >= 423 mu mol/L). A total of 167 patients, accounting for 21.9% of the sample, experienced postoperative AKI. The study found a significantly higher risk of AKI in the Q4 group compared to the Q1 group (40.4% v 8.9%; p < 0.001). After adjustment for confounding variables, an independent association between serum UA concentration and an elevated risk of AKI post-CABG was identified (odds ratio, 6.41; 95% confidence interval, 3.49-12.32; p < 0.001; p for trend < 0.001). Conclusions: There is a relationship between preoperative blood UA level and the occurrence of AKI following CABG surgery. (c) 2024 Elsevier Inc. All rights reserved.