Communication: High-Density Lipoprotein-Specific fi c Phospholipid Efflux ffl ux in Familial Hypercholesterolemia

被引：0
|
作者：
Sato, Masaki [1 ,2 ]
Hamasaki, Masato [1 ,2 ]
Neufeld, Edward B. [3 ]
Remaley, Alan T. [3 ,4 ]
Kotani, Kazuhiko [1 ]
机构：
[1] Jichi Med Univ, Div Community & Family Med, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan
[2] Eiken Chem Co Ltd, Biochem Res Lab, Nogi, Tochigi, Japan
[3] NHLBI, Lipoprotein Metab Lab, NIH, Bethesda, MD USA
[4] NIH, NIH Clin Ctr, Bethesda, MD USA
来源：
ANNALS OF CLINICAL AND LABORATORY SCIENCE | 2024年 / 54卷 / 03期
关键词：
apolipoprotein A-I; cardiovascular disease; cholesterol efflux capacity; hypercholesterolemia; high-density lipoprotein; phospholipid efflux; APOLIPOPROTEIN-A-I; HDL; ABNORMALITIES;
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objective. Familial hypercholesterolemia (FH) is characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD). Although the role of LDL-C in FH has been studied, the contribution of high-density lipoproteins (HDL) to CVD in FH remains unknown. This study aimed at highlighting the role of HDL in FH. Methods. HDL-specific phospholipid efflux (HDL-SPE) assay was developed to predict CVD risk. HDL-SPE was examined in FH patients (n=30) and compared with age- and sex-matched non-FH controls (n=60). Results. FH patients had significantly lower HDL-SPE levels (0.90 +/- 0.12) than controls (1.12 +/- 0.10; p<0.05), despite similar HDL-cholesterol levels in after adjusting for confounders. Conclusions. These findings suggest there may be dysfunctionality of HDL in FH.
引用
收藏
页码：419 / 422
页数：4
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